Hereditary Ovarian Carcinoma: Cancer Pathogenesis Looking beyond BRCA1 and BRCA2

David Samuel, Alexandra Diaz-Barbe, Andre Pinto, Matthew Schlumbrecht, Sophia George

Research output: Contribution to journalReview articlepeer-review


Besides BRCA1 and BRCA2, several other inheritable mutations have been identified that increase ovarian cancer risk. Surgical excision of the fallopian tubes and ovaries reduces ovarian cancer risk, but for some non-BRCA hereditary ovarian cancer mutations the benefit of this inter-vention is unclear. The fallopian tubes of women with hereditary ovarian cancer mutations provide many insights into the early events of carcinogenesis and process of malignant transformation. Here we review cancer pathogenesis in hereditary cases of ovarian cancer, the occurrence of pre-invasive lesions and occult carcinoma in mutation carriers and their clinical management.

Original languageEnglish (US)
Article number539
Issue number3
StatePublished - Feb 1 2022
Externally publishedYes


  • ATM
  • BRCA1
  • BRCA2
  • BRIP1
  • Carcino-genesis
  • Hereditary breast and ovarian cancer syndrome
  • MRE11
  • NBN
  • Ovarian cancer pathogenesis
  • PALB2
  • RAD50
  • RAD51
  • STIC
  • Serous tubal intraepithelial carcinoma

ASJC Scopus subject areas

  • Medicine(all)


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