Hereditary motor and sensory neuropathy, X-linked: A half century follow-up

M. P. Rozear, M. A. Pericak-Vance, K. Fischbeck, J. M. Stajich, P. C. Gaskell, D. A. Krendel, D. G. Graham, D. V. Dawson, A. D. Roses

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

The existence of an X-linked sensorimotor peripheral neuropathy has been debated. We reevaluated the original family, and present data on 13 affected males and 25 obligate or probable heterozygous females, documenting the devastating nature of the disease in the men and the extremely variable degree of clinical involvement in the carriers. Use of DNA probes indicates that the gene lies in the DXYS1-p58-1 region of the X-chromosome.

Original languageEnglish (US)
Pages (from-to)1460-1465
Number of pages6
JournalNeurology
Volume37
Issue number9
DOIs
StatePublished - Sep 1987

ASJC Scopus subject areas

  • Clinical Neurology

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    Rozear, M. P., Pericak-Vance, M. A., Fischbeck, K., Stajich, J. M., Gaskell, P. C., Krendel, D. A., Graham, D. G., Dawson, D. V., & Roses, A. D. (1987). Hereditary motor and sensory neuropathy, X-linked: A half century follow-up. Neurology, 37(9), 1460-1465. https://doi.org/10.1212/wnl.37.9.1460