HER2 therapy: HER2 (ERBB2): Functional diversity from structurally conserved building blocks

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

EGFR-type receptor tyrosine kinases achieve a broad spectrum of cellular responses by utilizing a set of structurally conserved building blocks. Based on available crystal structures and biochemical information, significant new insights have emerged into modes of receptor control, its deregulation in cancer, and the nuances that differentiate the four human receptors. This review gives an overview of current models of the control of receptor activity with a special emphasis on HER2 and HER3.

Original languageEnglish (US)
Article number202
JournalBreast Cancer Research
Volume9
Issue number1
DOIs
StatePublished - Jan 22 2007

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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