Hepatotoxicity secondary to chemotherapy

Alla Grigorian, Christopher B. O’brien

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations


The difficult problem faced by multiple generation of practi-cing physicians is determining the cause of abnormal liver function tests in cancer patients on chemotherapy. Hepatotoxicity from chemotherapy occurs frequently from an unpredictable or idiosyncratic reaction. Despite remark-able advances in our understanding of the mechanisms of action, pharmacodynamics, and interrelationships between the liver and chemotherapy, the underlying etiology of hepatic toxicity for various agents remains unexplained. Here, we present a concise review of the broad differential diagnosis for abnormal liver function tests (LFTs) in oncology patients.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalJournal of Clinical and Translational Hepatology
Issue number2
StatePublished - 2014


  • Cancer
  • Chemotherapy
  • Drugs
  • Hepatotoxicity
  • Liver

ASJC Scopus subject areas

  • Hepatology


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