Hepatotoxicity of antimicrobial, antifungal, and antiparasitic agents

K. R. Reddy, E. R. Schiff

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Several antibiotics are known to be hepatotoxic. Apart from subtle, reversible, and often inconsequential abnormalities, cholestasis is the predominant presentation that has a protracted and disabling course. Hepatitis, like illness, is characteristic of some drugs, and chronic Liver disease may evolve. It is important to recognize if a patient has an adverse reaction to a drug because continuing use of the drug in the face of hepatitis can have disastrous consequences. Chronic liver disease may ensue and progress onto cirrhosis; this has typically been seen following use of isoniazid and nitrofurantoin. Cholestatic liver disease can progress into a chronic form of a ductopenic state; this is particularly seen after antibiotic-related cholestasis.

Original languageEnglish (US)
Pages (from-to)923-936
Number of pages14
JournalGastroenterology Clinics of North America
Volume24
Issue number4
StatePublished - Dec 1 1995

ASJC Scopus subject areas

  • Gastroenterology

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