Hepatotoxicity in rat induced by partially purified toxins from Eupatorium adenophorum (Ageratina adenophora)

V. Kaushal, R. K. Dawra, O. P. Sharma, N. P. Kurade

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

A group of rats were administered a methanolic extract of Eupatorium adenophorum (Ageratina adenophora) oven-dried (60°C) leaf powder and a partially purified fraction from the methanolic extract. Administration of the methanolic extract and the partially purified fraction elicited a significant increase in total and conjugated bilirubin, alkaline phosphatase, 5'-nucleotidase and transaminases. Histopathology of the livers from these animals revealed dilated bile ducts and proliferative changes. Hepatocytes around the bile ducts showed necrotic changes. Biochemical and histopathological changes resembled those observed in response to administration of whole leaf powder. The hepatotoxin present in E. adenophorum leaves can be extracted with methanol and partially purified further using the procedure described. Copyright (C) 2000.

Original languageEnglish (US)
Pages (from-to)615-619
Number of pages5
JournalToxicon
Volume39
Issue number5
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Keywords

  • Bilirubin
  • Eupatorium adenophorum
  • Hepatotoxicity

ASJC Scopus subject areas

  • Toxicology

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