Hepatotoxicity and cholestasis in rats induced by the sesquiterpene, 9-oxo-10,11-dehydroageraphorone, isolated from Eupatorium adenophorum

Renu Bhardwaj, Ajay Singh, Om P. Sharma, Rajinder K. Dawra, Nitin P. Kurade, Shashi B. Mahato

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Eupatorium adenophorum leaves cause hepatotoxicity and cholestasis in rats. The hepatotoxicant has been characterized as 9-oxo-10,11-dehydroageraphorone (ODA), a cadinene sesquiterpene. Oral administration of ODA, mixed in feed to rats, caused jaundice in 24 h. The liver of the intoxicated animals had focal areas of hepatocellular necrosis, proliferation, and dilation of bile ducts with degenerative changes in the lining epithelium. There was marked increase in the conjugated form of plasma bilirubin and in the activities of the enzymes glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, alkaline phosphatase, lactate dehydrogenase, γ-glutamyltranspeptidase, glutamate dehydrogenase, and 5′-nucleotidase. The histopathological lesions in liver and biochemical profile of marker enzymes show that ODA induced hepatotoxicity and cholestasis in rats. This is the first report on the toxicity of a cadinene sesquiterpene in rats.

Original languageEnglish (US)
Pages (from-to)279-286
Number of pages8
JournalJournal of Biochemical and Molecular Toxicology
Volume15
Issue number5
DOIs
StatePublished - Dec 11 2001
Externally publishedYes

Keywords

  • 9-oxo-10,11-dehydroageraphorone
  • Eupatorium adenophorum
  • Hepatotoxicant
  • Hepatotoxicity
  • Sesquiterpene

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Toxicology
  • Health, Toxicology and Mutagenesis

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