Hepatosplenic gamma/delta T-cell lymphoma in bone marrow: A sinusoidal neoplasm with blastic cytologic features

F. Vega, L. J. Medeiros, C. Bueso-Ramos, D. Jones, R. Lai, R. Luthra, L. V. Abruzzo

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


We report 8 cases of hepatosplenic T-cell lymphoma (HSTCL) involving bone marrow and correlate histologic findings with disease progression. Immunophenotypic analysis demonstrated mature, aberrant gamma/delta T-cell immunophenotypes. Isochromosome 7q was identified in 4 cases; 1 case showed the t(7;14)(q34;q13). Seven of 7 cases tested had monoclonal TCR gamma gene rearrangements. The initial diagnostic bone marrow biopsy specimens were hypercellular with a frequently subtle, predominantly sinusoidal infiltrate of atypical small to medium-sized lymphoid cells. In all cases, aspirate smears at diagnosis and in subsequent specimens contained malignant cells that resembled blasts, some with fine cytoplasmic granules. With progression, the pattern of HSTCL in bone marrow biopsy specimens became increasingly interstitial, and the neoplastic cells became larger. In aspirate smears, the proportion of blasts increased. Seven patients died; I was lost to follow-up. Autopsy performed on 1 patient demonstrated malignant cells within vascular channels in all organs sampled, with relatively little tumor formation, resembling intravascular lymphoma at these sites. HSTCL often can be recognized in bone marrow by its unique combination of a sinusoidal pattern in core biopsy specimens and blastic cytology in aspirate smears.

Original languageEnglish (US)
Pages (from-to)410-419
Number of pages10
JournalAmerican journal of clinical pathology
Issue number3
StatePublished - 2001
Externally publishedYes


  • Bone marrow
  • Gamma/delta T-cell receptor
  • Hepatosplenic T-cell lymphoma
  • Immunophenotype

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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