Abstract
Introduction: Bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into multiple cell types, including osteoblasts, chondrocytes, and adipocytes. These pluripotent cells secrete hepatocyte growth factor (HGF), which regulates cell growth, survival, motility, migration, mitogenesis and is important for tissue development/regeneration. HGF has four splice variants, NK1, NK2, NK3, and NK4 which have varying functions and affinities for the HGF receptor, cMET. HGF promotes osteoblastic differentiation of MSCs into bone forming cells, playing a role in bone development, health and repair. Areas Covered: This review will focus on the effects of HGF in osteogenesis, bone repair and bone health, including structural and functional insights into the role of HGF in the body. Expert Opinion: Approximately 6.2 million Americans experience a fracture annually, with 5-10% being mal- or non-union fractures. HGF is important in priming MSCs for osteogenic differentiation in vitro and is currently being studied to assess its role during bone repair in vivo. Due to the high turnover rate of systemic HGF, non-classic modes of HGF-treatment, including naked-plasmid HGF delivery and the use of HGF splice variants (NK1 & NK2) are being studied to find safe and efficacious treatments for bone disorders, such as mal- or non-union fractures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-12 |
| Number of pages | 12 |
| Journal | Expert Opinion on Therapeutic Targets |
| DOIs | |
| State | Accepted/In press - Mar 21 2016 |
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Keywords
- Bone
- cMET
- Hepatocyte Growth Factor
- HGF
- Osteoblastic Differentiation
- Osteoblasts
- Osteoclasts
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
- Clinical Biochemistry
- Molecular Medicine
Cite this
Hepatocyte growth factor and alternative splice variants - expression, regulation and implications in osteogenesis and bone health and repair. / Frisch, Rachel N.; Curtis, Kevin M.; Aenlle, Kristina K.; Howard, Guy.
In: Expert Opinion on Therapeutic Targets, 21.03.2016, p. 1-12.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hepatocyte growth factor and alternative splice variants - expression, regulation and implications in osteogenesis and bone health and repair
AU - Frisch, Rachel N.
AU - Curtis, Kevin M.
AU - Aenlle, Kristina K.
AU - Howard, Guy
PY - 2016/3/21
Y1 - 2016/3/21
N2 - Introduction: Bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into multiple cell types, including osteoblasts, chondrocytes, and adipocytes. These pluripotent cells secrete hepatocyte growth factor (HGF), which regulates cell growth, survival, motility, migration, mitogenesis and is important for tissue development/regeneration. HGF has four splice variants, NK1, NK2, NK3, and NK4 which have varying functions and affinities for the HGF receptor, cMET. HGF promotes osteoblastic differentiation of MSCs into bone forming cells, playing a role in bone development, health and repair. Areas Covered: This review will focus on the effects of HGF in osteogenesis, bone repair and bone health, including structural and functional insights into the role of HGF in the body. Expert Opinion: Approximately 6.2 million Americans experience a fracture annually, with 5-10% being mal- or non-union fractures. HGF is important in priming MSCs for osteogenic differentiation in vitro and is currently being studied to assess its role during bone repair in vivo. Due to the high turnover rate of systemic HGF, non-classic modes of HGF-treatment, including naked-plasmid HGF delivery and the use of HGF splice variants (NK1 & NK2) are being studied to find safe and efficacious treatments for bone disorders, such as mal- or non-union fractures.
AB - Introduction: Bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into multiple cell types, including osteoblasts, chondrocytes, and adipocytes. These pluripotent cells secrete hepatocyte growth factor (HGF), which regulates cell growth, survival, motility, migration, mitogenesis and is important for tissue development/regeneration. HGF has four splice variants, NK1, NK2, NK3, and NK4 which have varying functions and affinities for the HGF receptor, cMET. HGF promotes osteoblastic differentiation of MSCs into bone forming cells, playing a role in bone development, health and repair. Areas Covered: This review will focus on the effects of HGF in osteogenesis, bone repair and bone health, including structural and functional insights into the role of HGF in the body. Expert Opinion: Approximately 6.2 million Americans experience a fracture annually, with 5-10% being mal- or non-union fractures. HGF is important in priming MSCs for osteogenic differentiation in vitro and is currently being studied to assess its role during bone repair in vivo. Due to the high turnover rate of systemic HGF, non-classic modes of HGF-treatment, including naked-plasmid HGF delivery and the use of HGF splice variants (NK1 & NK2) are being studied to find safe and efficacious treatments for bone disorders, such as mal- or non-union fractures.
KW - Bone
KW - cMET
KW - Hepatocyte Growth Factor
KW - HGF
KW - Osteoblastic Differentiation
KW - Osteoblasts
KW - Osteoclasts
UR - http://www.scopus.com/inward/record.url?scp=84961393872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961393872&partnerID=8YFLogxK
U2 - 10.1517/14728222.2016.1162293
DO - 10.1517/14728222.2016.1162293
M3 - Article
C2 - 26941128
AN - SCOPUS:84961393872
SP - 1
EP - 12
JO - Expert Opinion on Therapeutic Targets
JF - Expert Opinion on Therapeutic Targets
SN - 1472-8222
ER -