Hepatocellular carcinoma: Use of color doppler US to evaluate response to treatment with percutaneous ethanol injection

Riccardo Lencioni, Davide Caramella, Carlo Bartolozzi

Research output: Contribution to journalArticle

109 Scopus citations

Abstract

PURPOSE: To determine the usefulness of color Doppler ultrasound (US) in the evaluation of the response of hepatocellular carcinoma (HCC) to percutaneous ethanol injection (PEI). MATERIALS AND METHODS: Forty-one patients with 48 lesions 2-5 cm in diameter underwent color Doppler US before and after PEI. Computed tomography (CT), magnetic resonance (MR) imaging, and percutaneous biopsy were also performed to help establish the outcome of therapy. RESULTS: Before treatment, color signals with an arterial Doppler spectrum were seen in 44 of 48 lesions with a frequency shift of 0.51-4.11 kHz (mean, 1.65 kHz). After PEI, 37 of these lesions showed no color signal and were found to be necrotic at CT, MR imaging. and biopsy. In six of seven lesions containing residual tumor, pulsatile flow was still identified, although the frequency shift was significantly decreased (P = .01). CONCLUSION: Color Doppler US proved useful in the assessment of the therapeutic effect of PEI on HCC.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalRadiology
Volume194
Issue number1
DOIs
StatePublished - Jan 1995

Keywords

  • Alcohol
  • Liver neoplasms, US
  • Liver neoplasms, therapy
  • Liver, interventional procedure
  • Ultrasound (US), Doppler studies
  • Ultrasound (US), utilization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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