Hepatocellular carcinoma: Trends of incidence and survival in Europe and the United States at the end of the 20th century

Riccardo Capocaccia, Milena Sant, Franco Berrino, Arianna Simonetti, Valentina Santi, Franco Trevisani, W. Oberaigner, M. Jechova, M. Rousarova, H. H. Storm, T. Aareleid, T. Hakulinen, G. Hédelin, I. Tron, E. Le Gall, G. Launoy, J. Macé-Lesech, J. Faivre, G. Chaplain, P. M. CarliA. Danzon, B. Tretarre, M. Colonna, B. Lacour, N. Raverdy, C. Berger, F. Freycon, P. Grosclaude, J. Estève, P. Kaatsch, H. Ziegler, D. Hölzel, G. Schubert Fritschle, L. Tryggvadottir, C. Allemani, P. Baili, L. Ciccolallo, G. Gatta, A. Micheli, E. Taussig, E. Carrani, R. De Angelis, S. Hartley, P. Roazzi, M. Santaquilani, A. Tavilla, F. Valente, A. Verdecchia, S. Ferretti, P. Crosignani, P. Contiero, V. Ramazzotti, M. Vercelli, A. Quaglia, F. Pannelli, S. Vitarelli, P. Mosciatti, M. Federico, M. E. Artioli, M. Ponz De Leon, P. Benatti, V. De Lisi, L. Serventi, R. Zanetti, S. Patriarca, C. Magnani, G. Pastore, L. Gafà, R. Tumino, F. Falcini, M. Budroni, E. Paci, E. Crocetti, P. Zambon, S. Guzzinati, M. Dalmas, F. Langmark, A. Andersen, J. Rachtan, M. Bielska-Lasota, Z. Wronkowski, M. Zwierko, P. S. Pinheiro, I. Pleko, A. Obsitníková, V. Pompe-Kirn, I. Izarzugaza, C. Martinez-Garcia, I. Garau, C. Navarro, M. D. Chirlaque, E. Ardanaz, C. Moreno, J. Galceran, A. Torrella, R. Peris-Bonet, L. Barlow, T. Möller, G. Jundt, J. M. Lutz, M. Usel, J. W.W. Coebergh, A. Van Der Does-Van Den Berg, O. Visser, S. Godward, M. P. Coleman, E. M.I. Williams, D. Forman, M. J. Quinn, M. Roche, S. Edwards, S. Stiller, J. Verne, H. Møller, J. Bell, J. L. Botha, G. Lawrence, R. Black, D. Brewster, J. A. Steward

Research output: Contribution to journalArticlepeer-review

112 Scopus citations


OBJECTIVES: There is large geographic variation in incidence levels and time trends of hepatocellular carcinoma. We compared population-based liver cancer incidence and survival in European and U.S. populations in order to elucidate geographic differences and time trends for these variables. METHODS: Since comparisons based on cancer registry data are problematic because of variations in liver cancer definition and coding, we considered a subset of cases likely to be mainly hepatocellular carcinoma, suitable for international comparison. Incidence and 5-yr relative survival were calculated from cases diagnosed in five European regions (30,423 cases) and the United States (6,976 cases) in 1982-1994. RESULTS: Age-standardized incidence was highest in southern Europe (12/100,000 in men and 3/100,000 in women in 1992-94) and lowest in northern Europe, where incidence was similar to that of the United States (3/100,000 in men, <1/100,000 in women). Over the study period, incidence remained stable in the United States and most of Europe, except for a notable increase in southern Europe. Five-year relative survival was <10% in Europe, ranging from 8% (southern Europe) to 5% (eastern Europe), and 6% in the United States. Survival increased slightly with time, mainly in southern Europe and was unaffected by sex, but was better in younger patients. CONCLUSIONS: Increasing incidence in southern Europe is probably related to hepatitis B and C infection and increasing alcohol intake, while improving survival may be due to greater surveillance for cirrhosis. The survival gap between clinical and population-based series suggests management is better in centers of excellence.

Original languageEnglish (US)
Pages (from-to)1661-1670
Number of pages10
JournalAmerican Journal of Gastroenterology
Issue number8
StatePublished - Aug 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Hepatocellular carcinoma: Trends of incidence and survival in Europe and the United States at the end of the 20th century'. Together they form a unique fingerprint.

Cite this