Hepatocellular carcinoma: Trends of incidence and survival in Europe and the United States at the end of the 20th century

Riccardo Capocaccia, Milena Sant, Franco Berrino, Arianna Simonetti, Valentina Santi, Franco Trevisani, W. Oberaigner, M. Jechova, M. Rousarova, H. H. Storm, T. Aareleid, T. Hakulinen, G. Hédelin, I. Tron, E. Le Gall, G. Launoy, J. Macé-Lesech, J. Faivre, G. Chaplain, P. M. CarliA. Danzon, B. Tretarre, M. Colonna, B. Lacour, N. Raverdy, C. Berger, F. Freycon, P. Grosclaude, J. Estève, P. Kaatsch, H. Ziegler, D. Hölzel, G. Schubert Fritschle, L. Tryggvadottir, F. Berrino, C. Allemani, P. Baili, L. Ciccolallo, G. Gatta, A. Micheli, M. Sant, E. Taussig, R. Capocaccia, E. Carrani, R. De Angelis, S. Hartley, P. Roazzi, M. Santaquilani, A. Tavilla, F. Valente, A. Verdecchia, S. Ferretti, P. Crosignani, P. Contiero, V. Ramazzotti, M. Vercelli, A. Quaglia, F. Pannelli, S. Vitarelli, F. Pannelli, P. Mosciatti, M. Federico, M. E. Artioli, M. Ponz De Leon, P. Benatti, V. De Lisi, L. Serventi, R. Zanetti, S. Patriarca, C. Magnani, G. Pastore, L. Gafà, R. Tumino, F. Falcini, M. Budroni, E. Paci, E. Crocetti, P. Zambon, S. Guzzinati, M. Dalmas, F. Langmark, A. Andersen, J. Rachtan, M. Bielska-Lasota, Z. Wronkowski, M. Zwierko, P. S. Pinheiro, I. Pleko, A. Obsitníková, V. Pompe-Kirn, I. Izarzugaza, C. Martinez-Garcia, I. Garau, C. Navarro, M. D. Chirlaque, E. Ardanaz, C. Moreno, J. Galceran, A. Torrella, R. Peris-Bonet, L. Barlow, T. Möller, G. Jundt, J. M. Lutz, M. Usel, J. W.W. Coebergh, A. Van Der Does-Van Den Berg, O. Visser, S. Godward, M. P. Coleman, E. M.I. Williams, D. Forman, M. J. Quinn, M. Roche, S. Edwards, S. Stiller, J. Verne, H. Møller, J. Bell, J. L. Botha, G. Lawrence, R. Black, D. Brewster, J. A. Steward

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

OBJECTIVES: There is large geographic variation in incidence levels and time trends of hepatocellular carcinoma. We compared population-based liver cancer incidence and survival in European and U.S. populations in order to elucidate geographic differences and time trends for these variables. METHODS: Since comparisons based on cancer registry data are problematic because of variations in liver cancer definition and coding, we considered a subset of cases likely to be mainly hepatocellular carcinoma, suitable for international comparison. Incidence and 5-yr relative survival were calculated from cases diagnosed in five European regions (30,423 cases) and the United States (6,976 cases) in 1982-1994. RESULTS: Age-standardized incidence was highest in southern Europe (12/100,000 in men and 3/100,000 in women in 1992-94) and lowest in northern Europe, where incidence was similar to that of the United States (3/100,000 in men, <1/100,000 in women). Over the study period, incidence remained stable in the United States and most of Europe, except for a notable increase in southern Europe. Five-year relative survival was <10% in Europe, ranging from 8% (southern Europe) to 5% (eastern Europe), and 6% in the United States. Survival increased slightly with time, mainly in southern Europe and was unaffected by sex, but was better in younger patients. CONCLUSIONS: Increasing incidence in southern Europe is probably related to hepatitis B and C infection and increasing alcohol intake, while improving survival may be due to greater surveillance for cirrhosis. The survival gap between clinical and population-based series suggests management is better in centers of excellence.

Original languageEnglish (US)
Pages (from-to)1661-1670
Number of pages10
JournalAmerican Journal of Gastroenterology
Volume102
Issue number8
DOIs
StatePublished - Aug 1 2007
Externally publishedYes

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Hepatocellular Carcinoma
Survival
Incidence
Liver Neoplasms
Population
Eastern Europe
Hepatitis C
Hepatitis B
Registries
Fibrosis
Alcohols
Infection
Neoplasms

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Hepatocellular carcinoma : Trends of incidence and survival in Europe and the United States at the end of the 20th century. / Capocaccia, Riccardo; Sant, Milena; Berrino, Franco; Simonetti, Arianna; Santi, Valentina; Trevisani, Franco; Oberaigner, W.; Jechova, M.; Rousarova, M.; Storm, H. H.; Aareleid, T.; Hakulinen, T.; Hédelin, G.; Tron, I.; Le Gall, E.; Launoy, G.; Macé-Lesech, J.; Faivre, J.; Chaplain, G.; Carli, P. M.; Danzon, A.; Tretarre, B.; Colonna, M.; Lacour, B.; Raverdy, N.; Berger, C.; Freycon, F.; Grosclaude, P.; Estève, J.; Kaatsch, P.; Ziegler, H.; Hölzel, D.; Schubert Fritschle, G.; Tryggvadottir, L.; Berrino, F.; Allemani, C.; Baili, P.; Ciccolallo, L.; Gatta, G.; Micheli, A.; Sant, M.; Taussig, E.; Capocaccia, R.; Carrani, E.; De Angelis, R.; Hartley, S.; Roazzi, P.; Santaquilani, M.; Tavilla, A.; Valente, F.; Verdecchia, A.; Ferretti, S.; Crosignani, P.; Contiero, P.; Ramazzotti, V.; Vercelli, M.; Quaglia, A.; Pannelli, F.; Vitarelli, S.; Pannelli, F.; Mosciatti, P.; Federico, M.; Artioli, M. E.; Ponz De Leon, M.; Benatti, P.; De Lisi, V.; Serventi, L.; Zanetti, R.; Patriarca, S.; Magnani, C.; Pastore, G.; Gafà, L.; Tumino, R.; Falcini, F.; Budroni, M.; Paci, E.; Crocetti, E.; Zambon, P.; Guzzinati, S.; Dalmas, M.; Langmark, F.; Andersen, A.; Rachtan, J.; Bielska-Lasota, M.; Wronkowski, Z.; Zwierko, M.; Pinheiro, P. S.; Pleko, I.; Obsitníková, A.; Pompe-Kirn, V.; Izarzugaza, I.; Martinez-Garcia, C.; Garau, I.; Navarro, C.; Chirlaque, M. D.; Ardanaz, E.; Moreno, C.; Galceran, J.; Torrella, A.; Peris-Bonet, R.; Barlow, L.; Möller, T.; Jundt, G.; Lutz, J. M.; Usel, M.; Coebergh, J. W.W.; Van Der Does-Van Den Berg, A.; Visser, O.; Godward, S.; Coleman, M. P.; Williams, E. M.I.; Forman, D.; Quinn, M. J.; Roche, M.; Edwards, S.; Stiller, S.; Verne, J.; Møller, H.; Bell, J.; Botha, J. L.; Lawrence, G.; Black, R.; Brewster, D.; Steward, J. A.

In: American Journal of Gastroenterology, Vol. 102, No. 8, 01.08.2007, p. 1661-1670.

Research output: Contribution to journalArticle

Capocaccia, R, Sant, M, Berrino, F, Simonetti, A, Santi, V, Trevisani, F, Oberaigner, W, Jechova, M, Rousarova, M, Storm, HH, Aareleid, T, Hakulinen, T, Hédelin, G, Tron, I, Le Gall, E, Launoy, G, Macé-Lesech, J, Faivre, J, Chaplain, G, Carli, PM, Danzon, A, Tretarre, B, Colonna, M, Lacour, B, Raverdy, N, Berger, C, Freycon, F, Grosclaude, P, Estève, J, Kaatsch, P, Ziegler, H, Hölzel, D, Schubert Fritschle, G, Tryggvadottir, L, Berrino, F, Allemani, C, Baili, P, Ciccolallo, L, Gatta, G, Micheli, A, Sant, M, Taussig, E, Capocaccia, R, Carrani, E, De Angelis, R, Hartley, S, Roazzi, P, Santaquilani, M, Tavilla, A, Valente, F, Verdecchia, A, Ferretti, S, Crosignani, P, Contiero, P, Ramazzotti, V, Vercelli, M, Quaglia, A, Pannelli, F, Vitarelli, S, Pannelli, F, Mosciatti, P, Federico, M, Artioli, ME, Ponz De Leon, M, Benatti, P, De Lisi, V, Serventi, L, Zanetti, R, Patriarca, S, Magnani, C, Pastore, G, Gafà, L, Tumino, R, Falcini, F, Budroni, M, Paci, E, Crocetti, E, Zambon, P, Guzzinati, S, Dalmas, M, Langmark, F, Andersen, A, Rachtan, J, Bielska-Lasota, M, Wronkowski, Z, Zwierko, M, Pinheiro, PS, Pleko, I, Obsitníková, A, Pompe-Kirn, V, Izarzugaza, I, Martinez-Garcia, C, Garau, I, Navarro, C, Chirlaque, MD, Ardanaz, E, Moreno, C, Galceran, J, Torrella, A, Peris-Bonet, R, Barlow, L, Möller, T, Jundt, G, Lutz, JM, Usel, M, Coebergh, JWW, Van Der Does-Van Den Berg, A, Visser, O, Godward, S, Coleman, MP, Williams, EMI, Forman, D, Quinn, MJ, Roche, M, Edwards, S, Stiller, S, Verne, J, Møller, H, Bell, J, Botha, JL, Lawrence, G, Black, R, Brewster, D & Steward, JA 2007, 'Hepatocellular carcinoma: Trends of incidence and survival in Europe and the United States at the end of the 20th century', American Journal of Gastroenterology, vol. 102, no. 8, pp. 1661-1670. https://doi.org/10.1111/j.1572-0241.2007.01337.x
Capocaccia, Riccardo ; Sant, Milena ; Berrino, Franco ; Simonetti, Arianna ; Santi, Valentina ; Trevisani, Franco ; Oberaigner, W. ; Jechova, M. ; Rousarova, M. ; Storm, H. H. ; Aareleid, T. ; Hakulinen, T. ; Hédelin, G. ; Tron, I. ; Le Gall, E. ; Launoy, G. ; Macé-Lesech, J. ; Faivre, J. ; Chaplain, G. ; Carli, P. M. ; Danzon, A. ; Tretarre, B. ; Colonna, M. ; Lacour, B. ; Raverdy, N. ; Berger, C. ; Freycon, F. ; Grosclaude, P. ; Estève, J. ; Kaatsch, P. ; Ziegler, H. ; Hölzel, D. ; Schubert Fritschle, G. ; Tryggvadottir, L. ; Berrino, F. ; Allemani, C. ; Baili, P. ; Ciccolallo, L. ; Gatta, G. ; Micheli, A. ; Sant, M. ; Taussig, E. ; Capocaccia, R. ; Carrani, E. ; De Angelis, R. ; Hartley, S. ; Roazzi, P. ; Santaquilani, M. ; Tavilla, A. ; Valente, F. ; Verdecchia, A. ; Ferretti, S. ; Crosignani, P. ; Contiero, P. ; Ramazzotti, V. ; Vercelli, M. ; Quaglia, A. ; Pannelli, F. ; Vitarelli, S. ; Pannelli, F. ; Mosciatti, P. ; Federico, M. ; Artioli, M. E. ; Ponz De Leon, M. ; Benatti, P. ; De Lisi, V. ; Serventi, L. ; Zanetti, R. ; Patriarca, S. ; Magnani, C. ; Pastore, G. ; Gafà, L. ; Tumino, R. ; Falcini, F. ; Budroni, M. ; Paci, E. ; Crocetti, E. ; Zambon, P. ; Guzzinati, S. ; Dalmas, M. ; Langmark, F. ; Andersen, A. ; Rachtan, J. ; Bielska-Lasota, M. ; Wronkowski, Z. ; Zwierko, M. ; Pinheiro, P. S. ; Pleko, I. ; Obsitníková, A. ; Pompe-Kirn, V. ; Izarzugaza, I. ; Martinez-Garcia, C. ; Garau, I. ; Navarro, C. ; Chirlaque, M. D. ; Ardanaz, E. ; Moreno, C. ; Galceran, J. ; Torrella, A. ; Peris-Bonet, R. ; Barlow, L. ; Möller, T. ; Jundt, G. ; Lutz, J. M. ; Usel, M. ; Coebergh, J. W.W. ; Van Der Does-Van Den Berg, A. ; Visser, O. ; Godward, S. ; Coleman, M. P. ; Williams, E. M.I. ; Forman, D. ; Quinn, M. J. ; Roche, M. ; Edwards, S. ; Stiller, S. ; Verne, J. ; Møller, H. ; Bell, J. ; Botha, J. L. ; Lawrence, G. ; Black, R. ; Brewster, D. ; Steward, J. A. / Hepatocellular carcinoma : Trends of incidence and survival in Europe and the United States at the end of the 20th century. In: American Journal of Gastroenterology. 2007 ; Vol. 102, No. 8. pp. 1661-1670.
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title = "Hepatocellular carcinoma: Trends of incidence and survival in Europe and the United States at the end of the 20th century",
abstract = "OBJECTIVES: There is large geographic variation in incidence levels and time trends of hepatocellular carcinoma. We compared population-based liver cancer incidence and survival in European and U.S. populations in order to elucidate geographic differences and time trends for these variables. METHODS: Since comparisons based on cancer registry data are problematic because of variations in liver cancer definition and coding, we considered a subset of cases likely to be mainly hepatocellular carcinoma, suitable for international comparison. Incidence and 5-yr relative survival were calculated from cases diagnosed in five European regions (30,423 cases) and the United States (6,976 cases) in 1982-1994. RESULTS: Age-standardized incidence was highest in southern Europe (12/100,000 in men and 3/100,000 in women in 1992-94) and lowest in northern Europe, where incidence was similar to that of the United States (3/100,000 in men, <1/100,000 in women). Over the study period, incidence remained stable in the United States and most of Europe, except for a notable increase in southern Europe. Five-year relative survival was <10{\%} in Europe, ranging from 8{\%} (southern Europe) to 5{\%} (eastern Europe), and 6{\%} in the United States. Survival increased slightly with time, mainly in southern Europe and was unaffected by sex, but was better in younger patients. CONCLUSIONS: Increasing incidence in southern Europe is probably related to hepatitis B and C infection and increasing alcohol intake, while improving survival may be due to greater surveillance for cirrhosis. The survival gap between clinical and population-based series suggests management is better in centers of excellence.",
author = "Riccardo Capocaccia and Milena Sant and Franco Berrino and Arianna Simonetti and Valentina Santi and Franco Trevisani and W. Oberaigner and M. Jechova and M. Rousarova and Storm, {H. H.} and T. Aareleid and T. Hakulinen and G. H{\'e}delin and I. Tron and {Le Gall}, E. and G. Launoy and J. Mac{\'e}-Lesech and J. Faivre and G. Chaplain and Carli, {P. M.} and A. Danzon and B. Tretarre and M. Colonna and B. Lacour and N. Raverdy and C. Berger and F. Freycon and P. Grosclaude and J. Est{\`e}ve and P. Kaatsch and H. Ziegler and D. H{\"o}lzel and {Schubert Fritschle}, G. and L. Tryggvadottir and F. Berrino and C. Allemani and P. Baili and L. Ciccolallo and G. Gatta and A. Micheli and M. Sant and E. Taussig and R. Capocaccia and E. Carrani and {De Angelis}, R. and S. Hartley and P. Roazzi and M. Santaquilani and A. Tavilla and F. Valente and A. Verdecchia and S. Ferretti and P. Crosignani and P. Contiero and V. Ramazzotti and M. Vercelli and A. Quaglia and F. Pannelli and S. Vitarelli and F. Pannelli and P. Mosciatti and M. Federico and Artioli, {M. E.} and {Ponz De Leon}, M. and P. Benatti and {De Lisi}, V. and L. Serventi and R. Zanetti and S. Patriarca and C. Magnani and G. Pastore and L. Gaf{\`a} and R. Tumino and F. Falcini and M. Budroni and E. Paci and E. Crocetti and P. Zambon and S. Guzzinati and M. Dalmas and F. Langmark and A. Andersen and J. Rachtan and M. Bielska-Lasota and Z. Wronkowski and M. Zwierko and Pinheiro, {P. S.} and I. Pleko and A. Obsitn{\'i}kov{\'a} and V. Pompe-Kirn and I. Izarzugaza and C. Martinez-Garcia and I. Garau and C. Navarro and Chirlaque, {M. D.} and E. Ardanaz and C. Moreno and J. Galceran and A. Torrella and R. Peris-Bonet and L. Barlow and T. M{\"o}ller and G. Jundt and Lutz, {J. M.} and M. Usel and Coebergh, {J. W.W.} and {Van Der Does-Van Den Berg}, A. and O. Visser and S. Godward and Coleman, {M. P.} and Williams, {E. M.I.} and D. Forman and Quinn, {M. J.} and M. Roche and S. Edwards and S. Stiller and J. Verne and H. M{\o}ller and J. Bell and Botha, {J. L.} and G. Lawrence and R. Black and D. Brewster and Steward, {J. A.}",
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TY - JOUR

T1 - Hepatocellular carcinoma

T2 - Trends of incidence and survival in Europe and the United States at the end of the 20th century

AU - Capocaccia, Riccardo

AU - Sant, Milena

AU - Berrino, Franco

AU - Simonetti, Arianna

AU - Santi, Valentina

AU - Trevisani, Franco

AU - Oberaigner, W.

AU - Jechova, M.

AU - Rousarova, M.

AU - Storm, H. H.

AU - Aareleid, T.

AU - Hakulinen, T.

AU - Hédelin, G.

AU - Tron, I.

AU - Le Gall, E.

AU - Launoy, G.

AU - Macé-Lesech, J.

AU - Faivre, J.

AU - Chaplain, G.

AU - Carli, P. M.

AU - Danzon, A.

AU - Tretarre, B.

AU - Colonna, M.

AU - Lacour, B.

AU - Raverdy, N.

AU - Berger, C.

AU - Freycon, F.

AU - Grosclaude, P.

AU - Estève, J.

AU - Kaatsch, P.

AU - Ziegler, H.

AU - Hölzel, D.

AU - Schubert Fritschle, G.

AU - Tryggvadottir, L.

AU - Berrino, F.

AU - Allemani, C.

AU - Baili, P.

AU - Ciccolallo, L.

AU - Gatta, G.

AU - Micheli, A.

AU - Sant, M.

AU - Taussig, E.

AU - Capocaccia, R.

AU - Carrani, E.

AU - De Angelis, R.

AU - Hartley, S.

AU - Roazzi, P.

AU - Santaquilani, M.

AU - Tavilla, A.

AU - Valente, F.

AU - Verdecchia, A.

AU - Ferretti, S.

AU - Crosignani, P.

AU - Contiero, P.

AU - Ramazzotti, V.

AU - Vercelli, M.

AU - Quaglia, A.

AU - Pannelli, F.

AU - Vitarelli, S.

AU - Pannelli, F.

AU - Mosciatti, P.

AU - Federico, M.

AU - Artioli, M. E.

AU - Ponz De Leon, M.

AU - Benatti, P.

AU - De Lisi, V.

AU - Serventi, L.

AU - Zanetti, R.

AU - Patriarca, S.

AU - Magnani, C.

AU - Pastore, G.

AU - Gafà, L.

AU - Tumino, R.

AU - Falcini, F.

AU - Budroni, M.

AU - Paci, E.

AU - Crocetti, E.

AU - Zambon, P.

AU - Guzzinati, S.

AU - Dalmas, M.

AU - Langmark, F.

AU - Andersen, A.

AU - Rachtan, J.

AU - Bielska-Lasota, M.

AU - Wronkowski, Z.

AU - Zwierko, M.

AU - Pinheiro, P. S.

AU - Pleko, I.

AU - Obsitníková, A.

AU - Pompe-Kirn, V.

AU - Izarzugaza, I.

AU - Martinez-Garcia, C.

AU - Garau, I.

AU - Navarro, C.

AU - Chirlaque, M. D.

AU - Ardanaz, E.

AU - Moreno, C.

AU - Galceran, J.

AU - Torrella, A.

AU - Peris-Bonet, R.

AU - Barlow, L.

AU - Möller, T.

AU - Jundt, G.

AU - Lutz, J. M.

AU - Usel, M.

AU - Coebergh, J. W.W.

AU - Van Der Does-Van Den Berg, A.

AU - Visser, O.

AU - Godward, S.

AU - Coleman, M. P.

AU - Williams, E. M.I.

AU - Forman, D.

AU - Quinn, M. J.

AU - Roche, M.

AU - Edwards, S.

AU - Stiller, S.

AU - Verne, J.

AU - Møller, H.

AU - Bell, J.

AU - Botha, J. L.

AU - Lawrence, G.

AU - Black, R.

AU - Brewster, D.

AU - Steward, J. A.

PY - 2007/8/1

Y1 - 2007/8/1

N2 - OBJECTIVES: There is large geographic variation in incidence levels and time trends of hepatocellular carcinoma. We compared population-based liver cancer incidence and survival in European and U.S. populations in order to elucidate geographic differences and time trends for these variables. METHODS: Since comparisons based on cancer registry data are problematic because of variations in liver cancer definition and coding, we considered a subset of cases likely to be mainly hepatocellular carcinoma, suitable for international comparison. Incidence and 5-yr relative survival were calculated from cases diagnosed in five European regions (30,423 cases) and the United States (6,976 cases) in 1982-1994. RESULTS: Age-standardized incidence was highest in southern Europe (12/100,000 in men and 3/100,000 in women in 1992-94) and lowest in northern Europe, where incidence was similar to that of the United States (3/100,000 in men, <1/100,000 in women). Over the study period, incidence remained stable in the United States and most of Europe, except for a notable increase in southern Europe. Five-year relative survival was <10% in Europe, ranging from 8% (southern Europe) to 5% (eastern Europe), and 6% in the United States. Survival increased slightly with time, mainly in southern Europe and was unaffected by sex, but was better in younger patients. CONCLUSIONS: Increasing incidence in southern Europe is probably related to hepatitis B and C infection and increasing alcohol intake, while improving survival may be due to greater surveillance for cirrhosis. The survival gap between clinical and population-based series suggests management is better in centers of excellence.

AB - OBJECTIVES: There is large geographic variation in incidence levels and time trends of hepatocellular carcinoma. We compared population-based liver cancer incidence and survival in European and U.S. populations in order to elucidate geographic differences and time trends for these variables. METHODS: Since comparisons based on cancer registry data are problematic because of variations in liver cancer definition and coding, we considered a subset of cases likely to be mainly hepatocellular carcinoma, suitable for international comparison. Incidence and 5-yr relative survival were calculated from cases diagnosed in five European regions (30,423 cases) and the United States (6,976 cases) in 1982-1994. RESULTS: Age-standardized incidence was highest in southern Europe (12/100,000 in men and 3/100,000 in women in 1992-94) and lowest in northern Europe, where incidence was similar to that of the United States (3/100,000 in men, <1/100,000 in women). Over the study period, incidence remained stable in the United States and most of Europe, except for a notable increase in southern Europe. Five-year relative survival was <10% in Europe, ranging from 8% (southern Europe) to 5% (eastern Europe), and 6% in the United States. Survival increased slightly with time, mainly in southern Europe and was unaffected by sex, but was better in younger patients. CONCLUSIONS: Increasing incidence in southern Europe is probably related to hepatitis B and C infection and increasing alcohol intake, while improving survival may be due to greater surveillance for cirrhosis. The survival gap between clinical and population-based series suggests management is better in centers of excellence.

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U2 - 10.1111/j.1572-0241.2007.01337.x

DO - 10.1111/j.1572-0241.2007.01337.x

M3 - Article

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VL - 102

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EP - 1670

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

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