TY - JOUR
T1 - Hepatocellular carcinoma treatment with percutaneous ethanol injection
T2 - Evaluation with contrast-enhanced Color Doppler US
AU - Bartolozzi, Carlo
AU - Lencioni, Riccardo
AU - Ricci, Paolo
AU - Paolicchi, Alessandro
AU - Rossi, Plinio
AU - Passariello, Roberto
PY - 1998/11
Y1 - 1998/11
N2 - PURPOSE: To investigate the ability of contrast agent-enhanced color Doppler ultrasonography (US) in evaluating the response of hepatocellular carcinoma (HCC) to percutaneous ethanol injection (PEI). MATERIALS AND METHODS: Forty-two patients (36 men, six women; age range, 51-79 years) with 54 1.3-7.0-cm-diameter (mean ± SD, 2.8 cm ± 1.1) HCC lesions were examined with contrast-enhanced color Doppler US before and after PEI. Spiral computed tomography (CT) and percutaneous biopsy also were performed to establish the outcome of therapy. RESULTS: Before PEI, intratumoral color signals were demonstrated at contrast-enhanced color Doppler US in 47 (87%) lesions (in 40 patients) After PEI, blood flow signals were no longer detected in all 34 of the lesions that were found to be necrotic intratumoral color signals corresponding to the enhancing areas at spiral CT were still identified at contrast-enhanced color Doppler US. These 12 lesions were retreated with PEI by targeting the areas of residual tumor with contrast-enhanced color Doppler. CONCLUSION: Contrast-enhanced color Doppler US shows promise in assessing the therapeutic effect of PEI on HCC and in guiding additional treatment in cases of incomplete response.
AB - PURPOSE: To investigate the ability of contrast agent-enhanced color Doppler ultrasonography (US) in evaluating the response of hepatocellular carcinoma (HCC) to percutaneous ethanol injection (PEI). MATERIALS AND METHODS: Forty-two patients (36 men, six women; age range, 51-79 years) with 54 1.3-7.0-cm-diameter (mean ± SD, 2.8 cm ± 1.1) HCC lesions were examined with contrast-enhanced color Doppler US before and after PEI. Spiral computed tomography (CT) and percutaneous biopsy also were performed to establish the outcome of therapy. RESULTS: Before PEI, intratumoral color signals were demonstrated at contrast-enhanced color Doppler US in 47 (87%) lesions (in 40 patients) After PEI, blood flow signals were no longer detected in all 34 of the lesions that were found to be necrotic intratumoral color signals corresponding to the enhancing areas at spiral CT were still identified at contrast-enhanced color Doppler US. These 12 lesions were retreated with PEI by targeting the areas of residual tumor with contrast-enhanced color Doppler. CONCLUSION: Contrast-enhanced color Doppler US shows promise in assessing the therapeutic effect of PEI on HCC and in guiding additional treatment in cases of incomplete response.
KW - Alcohol
KW - Liver neoplasms
KW - Liver neoplasms, CT
KW - Liver neoplasms, US
KW - Liver, interventional procedure
KW - Ultrasound (US), Doppler studies
KW - Ultrasound (US), contrast media
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U2 - 10.1148/radiology.209.2.9807563
DO - 10.1148/radiology.209.2.9807563
M3 - Article
C2 - 9807563
AN - SCOPUS:0031728431
VL - 209
SP - 387
EP - 393
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 2
ER -