Abstract
Image-guided percutaneous ablation is currently accepted as the best therapeutic choice for patients with early-stage hepatocellular carcinoma (HCC) when transplantation and resection are precluded. Several methods for chemical or thermal tumor destruction have been developed and tested clinically during the past two decades. The seminal technique used for local treatment of HCC has been percutaneous ethanol injection (PEI). Several studies have provided indirect evidence that PEI improves the natural history of nonsurgical patients with early-stage HCC. Its major limitation is the high rate of local recurrence. Radiofrequency (RF) ablation has been the most widely assessed alternative to PEI. Five randomized controlled trials have shown that RF ablation achieves more effective and reproducible tumor destruction than PEI, leading to a better local control of the disease. As a result, RF ablation has been established as the primary ablative modality. The value of newer thermal and nonthermal methods for local tumor treatment, such as microwave ablation, irreversible electroporation (IRE), and light activated drug therapy, should be investigated in the setting of randomized controlled trials.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 399-403 |
| Number of pages | 5 |
| Journal | Journal of Hepato-Biliary-Pancreatic Sciences |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2010 |
| Externally published | Yes |
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Keywords
- Hepatocellular carcinoma
- Percutaneous ethanol injection
- Radiofrequency ablation
ASJC Scopus subject areas
- Medicine(all)
- Hepatology
- Surgery
Cite this
Hepatocellular carcinoma : New options for image-guided ablation. / Lencioni, Riccardo; Cioni, Dania; Della Pina, Clotilde; Crocetti, Laura.
In: Journal of Hepato-Biliary-Pancreatic Sciences, Vol. 17, No. 4, 07.2010, p. 399-403.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hepatocellular carcinoma
T2 - New options for image-guided ablation
AU - Lencioni, Riccardo
AU - Cioni, Dania
AU - Della Pina, Clotilde
AU - Crocetti, Laura
PY - 2010/7
Y1 - 2010/7
N2 - Image-guided percutaneous ablation is currently accepted as the best therapeutic choice for patients with early-stage hepatocellular carcinoma (HCC) when transplantation and resection are precluded. Several methods for chemical or thermal tumor destruction have been developed and tested clinically during the past two decades. The seminal technique used for local treatment of HCC has been percutaneous ethanol injection (PEI). Several studies have provided indirect evidence that PEI improves the natural history of nonsurgical patients with early-stage HCC. Its major limitation is the high rate of local recurrence. Radiofrequency (RF) ablation has been the most widely assessed alternative to PEI. Five randomized controlled trials have shown that RF ablation achieves more effective and reproducible tumor destruction than PEI, leading to a better local control of the disease. As a result, RF ablation has been established as the primary ablative modality. The value of newer thermal and nonthermal methods for local tumor treatment, such as microwave ablation, irreversible electroporation (IRE), and light activated drug therapy, should be investigated in the setting of randomized controlled trials.
AB - Image-guided percutaneous ablation is currently accepted as the best therapeutic choice for patients with early-stage hepatocellular carcinoma (HCC) when transplantation and resection are precluded. Several methods for chemical or thermal tumor destruction have been developed and tested clinically during the past two decades. The seminal technique used for local treatment of HCC has been percutaneous ethanol injection (PEI). Several studies have provided indirect evidence that PEI improves the natural history of nonsurgical patients with early-stage HCC. Its major limitation is the high rate of local recurrence. Radiofrequency (RF) ablation has been the most widely assessed alternative to PEI. Five randomized controlled trials have shown that RF ablation achieves more effective and reproducible tumor destruction than PEI, leading to a better local control of the disease. As a result, RF ablation has been established as the primary ablative modality. The value of newer thermal and nonthermal methods for local tumor treatment, such as microwave ablation, irreversible electroporation (IRE), and light activated drug therapy, should be investigated in the setting of randomized controlled trials.
KW - Hepatocellular carcinoma
KW - Percutaneous ethanol injection
KW - Radiofrequency ablation
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U2 - 10.1007/s00534-009-0233-0
DO - 10.1007/s00534-009-0233-0
M3 - Article
C2 - 20091187
AN - SCOPUS:79952112493
VL - 17
SP - 399
EP - 403
JO - Journal of Hepato-Biliary-Pancreatic Sciences
JF - Journal of Hepato-Biliary-Pancreatic Sciences
SN - 1868-6974
IS - 4
ER -