Hepatobiliary cryptosporidiosis and cytomegalovirus infection mimicking metastatic cancer to the liver

Fuad A. Hasan, Lennox J Jeffers, Gordon Dickinson, Christian L. Otrakji, Pedro J. Greer, K. Rajender Reddy, Eugene R Schiff

Research output: Contribution to journalArticle

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Abstract

A cholestatic syndrome caused by sclerosing cholangitis and papillary stenosis has been described in patients with the acquired immunodeficiency syndrome and hepatobiliary cryplosporidiosis and cytomegalovirus infection. The case of a 41-year-old homosexual man with the acquired immunodeficiency syndrome who presented with abdominal pain, diarrhea, fever, and cholestasis is reported. A percutaneous transhepatic cholangiogram showed that the extrahepatic and right-sided intrahepatic ducts were normal. Computerized tomography of the abdomen showed multiple hypodense lesions in the liver. Guided needle biopsies of several of these lesions showed severe confluent necrotizing pericholangitis with cytomegalovirus-infected cells. Numerous cryptosporidia were seen attached to biliary epithelium. The unique histopathologic and radiographic features of this case should be added to the spectrum of hepatobiliary manifestations of the acquired immunodeficiency syndrome.

Original languageEnglish
Pages (from-to)1743-1748
Number of pages6
JournalGastroenterology
Volume100
Issue number6
StatePublished - Dec 1 1991

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Cryptosporidiosis
Cytomegalovirus Infections
Liver Neoplasms
Acquired Immunodeficiency Syndrome
Sclerosing Cholangitis
Cryptosporidium
Cholestasis
Needle Biopsy
Cytomegalovirus
Abdomen
Abdominal Pain
Diarrhea
Pathologic Constriction
Fever
Epithelium
Tomography
Liver

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hasan, F. A., Jeffers, L. J., Dickinson, G., Otrakji, C. L., Greer, P. J., Reddy, K. R., & Schiff, E. R. (1991). Hepatobiliary cryptosporidiosis and cytomegalovirus infection mimicking metastatic cancer to the liver. Gastroenterology, 100(6), 1743-1748.

Hepatobiliary cryptosporidiosis and cytomegalovirus infection mimicking metastatic cancer to the liver. / Hasan, Fuad A.; Jeffers, Lennox J; Dickinson, Gordon; Otrakji, Christian L.; Greer, Pedro J.; Reddy, K. Rajender; Schiff, Eugene R.

In: Gastroenterology, Vol. 100, No. 6, 01.12.1991, p. 1743-1748.

Research output: Contribution to journalArticle

Hasan, FA, Jeffers, LJ, Dickinson, G, Otrakji, CL, Greer, PJ, Reddy, KR & Schiff, ER 1991, 'Hepatobiliary cryptosporidiosis and cytomegalovirus infection mimicking metastatic cancer to the liver', Gastroenterology, vol. 100, no. 6, pp. 1743-1748.
Hasan FA, Jeffers LJ, Dickinson G, Otrakji CL, Greer PJ, Reddy KR et al. Hepatobiliary cryptosporidiosis and cytomegalovirus infection mimicking metastatic cancer to the liver. Gastroenterology. 1991 Dec 1;100(6):1743-1748.
Hasan, Fuad A. ; Jeffers, Lennox J ; Dickinson, Gordon ; Otrakji, Christian L. ; Greer, Pedro J. ; Reddy, K. Rajender ; Schiff, Eugene R. / Hepatobiliary cryptosporidiosis and cytomegalovirus infection mimicking metastatic cancer to the liver. In: Gastroenterology. 1991 ; Vol. 100, No. 6. pp. 1743-1748.
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