Hepatitis Viruses

A. J. Uriel, P. Martin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The five hepatotropic viruses, hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis delta virus (HDV), and hepatitis E virus (HEV), are implicated in most cases of acute viral hepatitis. HAV and HEV are enterically transmitted, HDV and HCV are spread predominantly through parenteral exposure; HBV is also spread parenterally, through intimate contact, and by vertical transfer from mother to infant. Hepatitis viruses have a global distribution, HAV and HEV are endemic in most developing countries and HBV is highly endemic in sub-Saharan Africa and Asia. As hepatitis viruses are largely noncytopathic, liver damage in acute (and chronic) hepatitis reflects host immune responses, largely controlled by CD4 T-helper lymphocytes, directed at viral- or self-antigens expressed on the surface of infected hepatocytes via the major histocompatibility complex (MHC). Acute viral hepatitis characteristically presents with systemic complaints such as malaise and jaundice, and generally cannot be distinguished by clinical or biochemical features. HBV, HDV, and HCV also cause chronic hepatitis, with the risk of progression to cirrhosis and hepatocellular carcinoma. Effective vaccines are available for HAV and HBV. Although achieving viral eradication in chronic HBV and HCV with current therapies is not universal, newer antiviral drugs are promising.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Microbiology
PublisherElsevier Inc.
Pages354-375
Number of pages22
ISBN (Print)9780123739445
DOIs
StatePublished - Jan 1 2009

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Hepatitis Viruses
Hepatitis B virus
Hepatitis A virus
Hepatitis D
Hepatitis Delta Virus
Hepatitis E virus
Hepacivirus
Chronic Hepatitis
Hepatitis
Africa South of the Sahara
Chronic Hepatitis B
Autoantigens
Helper-Inducer T-Lymphocytes
Jaundice
Major Histocompatibility Complex
Developing Countries
Antiviral Agents
Hepatocytes
Hepatocellular Carcinoma
Fibrosis

Keywords

  • Cirrhosis
  • Hepatitis A virus
  • Hepatitis B virus
  • Hepatitis C virus
  • Hepatitis D virus
  • Hepatitis E virus
  • Hepatocellular carcinoma
  • Jaundice
  • Viral hepatitis
  • Virology

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Uriel, A. J., & Martin, P. (2009). Hepatitis Viruses. In Encyclopedia of Microbiology (pp. 354-375). Elsevier Inc.. https://doi.org/10.1016/B978-012373944-5.00304-7

Hepatitis Viruses. / Uriel, A. J.; Martin, P.

Encyclopedia of Microbiology. Elsevier Inc., 2009. p. 354-375.

Research output: Chapter in Book/Report/Conference proceedingChapter

Uriel, AJ & Martin, P 2009, Hepatitis Viruses. in Encyclopedia of Microbiology. Elsevier Inc., pp. 354-375. https://doi.org/10.1016/B978-012373944-5.00304-7
Uriel AJ, Martin P. Hepatitis Viruses. In Encyclopedia of Microbiology. Elsevier Inc. 2009. p. 354-375 https://doi.org/10.1016/B978-012373944-5.00304-7
Uriel, A. J. ; Martin, P. / Hepatitis Viruses. Encyclopedia of Microbiology. Elsevier Inc., 2009. pp. 354-375
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