Hepatitis in children with acquired immune deficiency syndrome. Histopathologic and immunocytologic features

Lynn F. Duffy, Fredric Daum, Ellen Kahn, Saul Teichberg, Rajendra Pahwa, James Fagin, Kenneth Kenigsberg, Mark Kaplan, Stanley E. Fisher, Savita Pahwa

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Hepatic morphology and immunocytology were evaluated in 4 children with clinical and immunologic characteristics of the acquired immune deficiency syndrome or acquired immune deficiency syndrome-related complex. All 4 children had hepatomegaly and increased serum alanine and aspartate aminotransferase activity. Both lobular and portal changes were noted. Lymphocytic infiltration, piecemeal necrosis, hepatocellular and bile duct damage, sinusoidal cell hyperplasia, and endothelialitis were prominent. Vesicular rosettes in sinusoidal lymphocytes and tubuloreticular structures in sinusoidal endothelial cells were demonstrated by electron microscopy. The lymphocytic infiltrate in both the lobular and portal spaces was characterized by a relative increase of cytotoxic/suppressor (T8) cells. Hepatitis may be a common feature of pediatrie acquired immune deficiency syndrome and acquired immune deficiency syndrome-related complex. Although the histopathologic changes are consistent with chronic active hepatitis, the specific pathogenesis remains to be determined.

Original languageEnglish (US)
Pages (from-to)173-181
Number of pages9
JournalGastroenterology
Volume90
Issue number1
DOIs
StatePublished - Jan 1986

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Hepatitis in children with acquired immune deficiency syndrome. Histopathologic and immunocytologic features'. Together they form a unique fingerprint.

  • Cite this

    Duffy, L. F., Daum, F., Kahn, E., Teichberg, S., Pahwa, R., Fagin, J., Kenigsberg, K., Kaplan, M., Fisher, S. E., & Pahwa, S. (1986). Hepatitis in children with acquired immune deficiency syndrome. Histopathologic and immunocytologic features. Gastroenterology, 90(1), 173-181. https://doi.org/10.1016/0016-5085(86)90090-9