Hepatitis in children with acquired immune deficiency syndrome. Histopathologic and immunocytologic features

Lynn F. Duffy, Fredric Daum, Ellen Kahn, Saul Teichberg, Rajendra Pahwa, James Fagin, Kenneth Kenigsberg, Mark Kaplan, Stanley E. Fisher, Savita G Pahwa

Research output: Contribution to journalArticle

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Abstract

Hepatic morphology and immunocytology were evaluated in 4 children with clinical and immunologic characteristics of the acquired immune deficiency syndrome or acquired immune deficiency syndrome-related complex. All 4 children had hepatomegaly and increased serum alanine and aspartate aminotransferase activity. Both lobular and portal changes were noted. Lymphocytic infiltration, piecemeal necrosis, hepatocellular and bile duct damage, sinusoidal cell hyperplasia, and endothelialitis were prominent. Vesicular rosettes in sinusoidal lymphocytes and tubuloreticular structures in sinusoidal endothelial cells were demonstrated by electron microscopy. The lymphocytic infiltrate in both the lobular and portal spaces was characterized by a relative increase of cytotoxic/suppressor (T8) cells. Hepatitis may be a common feature of pediatrie acquired immune deficiency syndrome and acquired immune deficiency syndrome-related complex. Although the histopathologic changes are consistent with chronic active hepatitis, the specific pathogenesis remains to be determined.

Original languageEnglish
Pages (from-to)173-181
Number of pages9
JournalGastroenterology
Volume90
Issue number1
StatePublished - Jan 1 1986
Externally publishedYes

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Hepatitis
Acquired Immunodeficiency Syndrome
CD8-Positive T-Lymphocytes
Hepatomegaly
Chronic Hepatitis
Aspartate Aminotransferases
Bile Ducts
Alanine Transaminase
Hyperplasia
Electron Microscopy
Necrosis
Endothelial Cells
Lymphocytes
Liver
Serum

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Duffy, L. F., Daum, F., Kahn, E., Teichberg, S., Pahwa, R., Fagin, J., ... Pahwa, S. G. (1986). Hepatitis in children with acquired immune deficiency syndrome. Histopathologic and immunocytologic features. Gastroenterology, 90(1), 173-181.

Hepatitis in children with acquired immune deficiency syndrome. Histopathologic and immunocytologic features. / Duffy, Lynn F.; Daum, Fredric; Kahn, Ellen; Teichberg, Saul; Pahwa, Rajendra; Fagin, James; Kenigsberg, Kenneth; Kaplan, Mark; Fisher, Stanley E.; Pahwa, Savita G.

In: Gastroenterology, Vol. 90, No. 1, 01.01.1986, p. 173-181.

Research output: Contribution to journalArticle

Duffy, LF, Daum, F, Kahn, E, Teichberg, S, Pahwa, R, Fagin, J, Kenigsberg, K, Kaplan, M, Fisher, SE & Pahwa, SG 1986, 'Hepatitis in children with acquired immune deficiency syndrome. Histopathologic and immunocytologic features', Gastroenterology, vol. 90, no. 1, pp. 173-181.
Duffy LF, Daum F, Kahn E, Teichberg S, Pahwa R, Fagin J et al. Hepatitis in children with acquired immune deficiency syndrome. Histopathologic and immunocytologic features. Gastroenterology. 1986 Jan 1;90(1):173-181.
Duffy, Lynn F. ; Daum, Fredric ; Kahn, Ellen ; Teichberg, Saul ; Pahwa, Rajendra ; Fagin, James ; Kenigsberg, Kenneth ; Kaplan, Mark ; Fisher, Stanley E. ; Pahwa, Savita G. / Hepatitis in children with acquired immune deficiency syndrome. Histopathologic and immunocytologic features. In: Gastroenterology. 1986 ; Vol. 90, No. 1. pp. 173-181.
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