Hepatitis C Virus Infection Increases the Risk of Developing Chronic Kidney Disease

A Systematic Review and Meta-Analysis

Fabrizio Fabrizi, Simona Verdesca, Piergiorgio Messa, Paul Martin

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Background and Rationale: Chronic kidney disease and hepatitis C virus are prevalent in the general population worldwide, and controversy exists about the impact of HCV infection on the development and progression of kidney disease. Design: A systematic review of the published medical literature was made to assess whether positive anti-HCV serologic status plays an independent impact on the development of chronic kidney disease in the adult general population. We used a random-effects model to generate a summary estimate of the relative risk of chronic kidney disease (defined by reduced glomerular filtration rate or detectable proteinuria) with HCV across the published studies. Meta-regression and stratified analysis were also conducted. Results: Twenty-three studies (n = 2,842,421 patients) were eligible, and separate meta-analyses were performed according to the outcome. Pooling results of longitudinal studies (n = 9; 1,947,034 unique patients) demonstrated a relationship between positive HCV serologic status and increased incidence of chronic kidney disease, the summary estimate for adjusted hazard ratio was 1.43 (95 % confidence interval 1.23; 1.63, P = 0.0001), and between-studies heterogeneity was noted (P value by Q test

Original languageEnglish (US)
Pages (from-to)3801-3813
Number of pages13
JournalDigestive Diseases and Sciences
Volume60
Issue number12
DOIs
StatePublished - Dec 1 2015

Fingerprint

Virus Diseases
Chronic Renal Insufficiency
Hepacivirus
Meta-Analysis
Kidney Diseases
Chronic Hepatitis
Glomerular Filtration Rate
Proteinuria
Population
Longitudinal Studies
Regression Analysis
Confidence Intervals
Incidence
Infection

Keywords

  • Adult population
  • Chronic kidney disease
  • Hepatitis C
  • Meta-analysis
  • Proteinuria

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Hepatitis C Virus Infection Increases the Risk of Developing Chronic Kidney Disease : A Systematic Review and Meta-Analysis. / Fabrizi, Fabrizio; Verdesca, Simona; Messa, Piergiorgio; Martin, Paul.

In: Digestive Diseases and Sciences, Vol. 60, No. 12, 01.12.2015, p. 3801-3813.

Research output: Contribution to journalArticle

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