Hepatitis C virus infection and post-transplant diabetes mellitus among renal transplant patients: A meta-analysis

Fabrizio Fabrizi, P. Messa, Paul Martin, B. Takkouche

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Objective: To examine the association between HCV infection and the occurrence of post-transplant diabetes mellitus (PTDM) among renal transplant patients. Design: Meta-analysis of observational studies. Data Sources: We retrieved studies published in any language by systematically searching Medline, and Embase and by manually examining the references of the original articles, reviews, and monographs retrieved. Review Methods: We included cohort and case-control studies reporting relative risk estimates and 95% confidence intervals (CIs) for PTDM occurrence with HCV after renal transplantation. Thirteen studies providing information on a total of 30,099 unique patients were included in our meta-analysis. Results: Study-specific relative risks were weighted by the inverse of their variance to obtain fixed-and random-effects pooled estimates. The pooled relative risk (RR) for PTDM after RT was 2.73 with a 95% confidence interval (CI) of 1.94; 3.83 (10 studies). In a stratified analysis including only large studies (2 studies), the pooled RR was 1.36 (95% CI, 1.21; 1.54). Egger's regression test showed some evidence of publication bias (p=0.0001), but our sensitivity analysis showed that this issue did not meaningfully change the results. Conclusions: Our study shows a marked increase of the risk of post-transplant diabetes mellitus in anti-hepatitis C virus-positive renal transplant recipients. The excess risk of death in hepatitis C virus-positive renal transplant recipients may be at least partially attributed to post-transplant diabetes mellitus with its attendant complications.

Original languageEnglish
Pages (from-to)675-682
Number of pages8
JournalInternational Journal of Artificial Organs
Volume31
Issue number8
StatePublished - Aug 1 2008
Externally publishedYes

Fingerprint

Transplants
Virus Diseases
Medical problems
Viruses
Hepacivirus
Meta-Analysis
Diabetes Mellitus
Kidney
Confidence Intervals
Publication Bias
Information Storage and Retrieval
Transplantation (surgical)
Kidney Transplantation
Observational Studies
Case-Control Studies
Language
Sensitivity analysis
Infection

Keywords

  • Hepatitis C Virus (HCV)
  • Meta-analysis
  • Post-transplant diabetes mellitus
  • Renal transplantation

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

Cite this

Hepatitis C virus infection and post-transplant diabetes mellitus among renal transplant patients : A meta-analysis. / Fabrizi, Fabrizio; Messa, P.; Martin, Paul; Takkouche, B.

In: International Journal of Artificial Organs, Vol. 31, No. 8, 01.08.2008, p. 675-682.

Research output: Contribution to journalArticle

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