Hepatitis C infection in two urban hemodialysis units

Lennox J. Jeffers, Guido O. Perez, Maria D. De Medina, Carmen J. Ortiz-Interian, Eugene R. Schiff, K. Rajender Reddy, Margarita Jimenez, Jacques J. Bourgoignie, Carlos A. Vaamonde, Robert Duncan, Michael Houghton, George Lim Choo, George Kuo

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103 Scopus citations


We determined the prevalence of antibodies to the hepatitis C virus (anti-HCV) in 90 patients and 37 staff members of two hemodialysis units utilizing a recently developed anti-HCV recombinant based assay. Eleven patients (12%) were anti-HCV (+). Of these, eight (73%) had antibodies to the hepatitis B core antigen (anti-HBc) indicating prior hepatitis B infection; one patient was hepatitis B surface antigen (HBsAg) (+). All staff members were anti-HCV (-), although seven (19%) of them were anti-HBc (+). Alanine aminotransferase elevations were present at the time of the study in four anti-HCV (-) patients and in only one anti-HCV (+) patient. All anti-HCV (+) (mean 59 ± 74; range 3 to 269 units) and 85% of anti-HCV (-) patients (mean 16 ± 27; range 0 to 204 units) had received multiple blood transfusions (P = 0.348). Among 50 patients tested for human immunodeficiency virus (HIV), 43% of anti-HCV (+) as compared to only 7% anti-HCV (-) were positive (P = 0.003). There was a history of intravenous drug abuse (IVDA) in eight (72%) of the anti-HCV (+) patients and in only seven (9%) of the anti-HCV (-) group (P = 0.00001). The results of this serologic survey suggests that anti-HCV positivity is prevalent, although much less than anti-HBc, among our dialysis patients, whereas it was not detected among staff members. The prevalence rate of anti-HCV was statistically significantly higher among anti-HIV (+) and IVDA patients but not in multi-transfused patients.

Original languageEnglish (US)
Pages (from-to)320-322
Number of pages3
JournalKidney international
Issue number2
StatePublished - Aug 1990

ASJC Scopus subject areas

  • Nephrology

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    Jeffers, L. J., Perez, G. O., De Medina, M. D., Ortiz-Interian, C. J., Schiff, E. R., Reddy, K. R., Jimenez, M., Bourgoignie, J. J., Vaamonde, C. A., Duncan, R., Houghton, M., Choo, G. L., & Kuo, G. (1990). Hepatitis C infection in two urban hemodialysis units. Kidney international, 38(2), 320-322. https://doi.org/10.1038/ki.1990.203