Abstract
We evaluated the contribution of hepatitis C virus infection to liver disease in patients with sickle cell anemia. Antibody to hepatitis C virus (anti-HCV) by commercial enzyme immunoassay and a second confirmatory assay were assayed in 121 consecutive patients with sickle cell anemia. Anti-HCV was detected in 25 of 121 patients (20.7%). Of patients transfused >10 units of blood products, 30.3% were anti-HCV seropositive, whereas 8.6% of those patients who transfused <10 units were seropositive. In 11 of the 121 patients, serum alanine aminotransferase levels were repeatedly elevated. Nine of these 11 patients were anti-HCV seropositive, one was positive for hepatitis B surface antigen, and one was negative for all viral markers. In contrast, of 110 patients with normal serum alanine aminotransferase levels, only 14% were anti-HCV seropositive. In patients with sickle cell anemia, exposure to hepatitis C is common, related to the number of previous transfusions, and the most likely cause of persistently elevated aminotransferase levels.
| Original language | English |
|---|---|
| Pages (from-to) | 206-209 |
| Number of pages | 4 |
| Journal | Journal of Clinical Gastroenterology |
| Volume | 18 |
| Issue number | 3 |
| State | Published - Jan 1 1994 |
| Externally published | Yes |
Fingerprint
Keywords
- Hepatitis C
- Liver tests
- Sickle Cell Anemia
ASJC Scopus subject areas
- Gastroenterology
Cite this
Hepatitis C in sickle cell anemia. / DeVault, K. R.; Friedman, L. S.; Westerberg, S.; Martin, Paul; Hosein, B.; Ballas, S. K.
In: Journal of Clinical Gastroenterology, Vol. 18, No. 3, 01.01.1994, p. 206-209.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hepatitis C in sickle cell anemia
AU - DeVault, K. R.
AU - Friedman, L. S.
AU - Westerberg, S.
AU - Martin, Paul
AU - Hosein, B.
AU - Ballas, S. K.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - We evaluated the contribution of hepatitis C virus infection to liver disease in patients with sickle cell anemia. Antibody to hepatitis C virus (anti-HCV) by commercial enzyme immunoassay and a second confirmatory assay were assayed in 121 consecutive patients with sickle cell anemia. Anti-HCV was detected in 25 of 121 patients (20.7%). Of patients transfused >10 units of blood products, 30.3% were anti-HCV seropositive, whereas 8.6% of those patients who transfused <10 units were seropositive. In 11 of the 121 patients, serum alanine aminotransferase levels were repeatedly elevated. Nine of these 11 patients were anti-HCV seropositive, one was positive for hepatitis B surface antigen, and one was negative for all viral markers. In contrast, of 110 patients with normal serum alanine aminotransferase levels, only 14% were anti-HCV seropositive. In patients with sickle cell anemia, exposure to hepatitis C is common, related to the number of previous transfusions, and the most likely cause of persistently elevated aminotransferase levels.
AB - We evaluated the contribution of hepatitis C virus infection to liver disease in patients with sickle cell anemia. Antibody to hepatitis C virus (anti-HCV) by commercial enzyme immunoassay and a second confirmatory assay were assayed in 121 consecutive patients with sickle cell anemia. Anti-HCV was detected in 25 of 121 patients (20.7%). Of patients transfused >10 units of blood products, 30.3% were anti-HCV seropositive, whereas 8.6% of those patients who transfused <10 units were seropositive. In 11 of the 121 patients, serum alanine aminotransferase levels were repeatedly elevated. Nine of these 11 patients were anti-HCV seropositive, one was positive for hepatitis B surface antigen, and one was negative for all viral markers. In contrast, of 110 patients with normal serum alanine aminotransferase levels, only 14% were anti-HCV seropositive. In patients with sickle cell anemia, exposure to hepatitis C is common, related to the number of previous transfusions, and the most likely cause of persistently elevated aminotransferase levels.
KW - Hepatitis C
KW - Liver tests
KW - Sickle Cell Anemia
UR - http://www.scopus.com/inward/record.url?scp=0028205613&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028205613&partnerID=8YFLogxK
M3 - Article
C2 - 8034915
AN - SCOPUS:0028205613
VL - 18
SP - 206
EP - 209
JO - Journal of Clinical Gastroenterology
JF - Journal of Clinical Gastroenterology
SN - 0192-0790
IS - 3
ER -