TY - JOUR
T1 - Hepatitis C in sickle cell anemia
AU - DeVault, Kenneth R.
AU - Friedman, Lawrence S.
AU - Westerberg, Sharon
AU - Martin, Paul
AU - Hosein, Barbara
AU - Ballas, Samir K.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1994/4
Y1 - 1994/4
N2 - We evaluated the contribution of hepatitis C virus infection to liver disease in patients with sickle cell anemia. Antibody to hepatitis C virus (anti-HCV) by commercial enzyme immunoassay and a second confirmatory assay were assayed in 121 consecutive patients with sickle cell anemia. Anti-HCV was detected in 25 of 121 patients (20.7%). Of patients transfused >10 units of blood products, 30.3% were anti-HCV seropositive, whereas 8.6% of those patients who transfused <10 units were seropositive. In 11 of the 121 patients, serum alanine aminotransferase levels were repeatedly elevated. Nine of these 11 patients were anti-HCV seropositive, one was positive for hepatitis B surface antigen, and one was negative for all viral markers. In contrast, of 110 patients with normal serum alanine aminotransferase levels, only 14% were anti-HCV seropositive. In patients with sickle cell anemia, exposure to hepatitis C is common, related to the number of previous transfusions, and the most likely cause of persistently elevated aminotransferase levels.
AB - We evaluated the contribution of hepatitis C virus infection to liver disease in patients with sickle cell anemia. Antibody to hepatitis C virus (anti-HCV) by commercial enzyme immunoassay and a second confirmatory assay were assayed in 121 consecutive patients with sickle cell anemia. Anti-HCV was detected in 25 of 121 patients (20.7%). Of patients transfused >10 units of blood products, 30.3% were anti-HCV seropositive, whereas 8.6% of those patients who transfused <10 units were seropositive. In 11 of the 121 patients, serum alanine aminotransferase levels were repeatedly elevated. Nine of these 11 patients were anti-HCV seropositive, one was positive for hepatitis B surface antigen, and one was negative for all viral markers. In contrast, of 110 patients with normal serum alanine aminotransferase levels, only 14% were anti-HCV seropositive. In patients with sickle cell anemia, exposure to hepatitis C is common, related to the number of previous transfusions, and the most likely cause of persistently elevated aminotransferase levels.
KW - Hepatitis C
KW - Liver tests
KW - Sickle Cell Anemia
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U2 - 10.1097/00004836-199404000-00006
DO - 10.1097/00004836-199404000-00006
M3 - Article
C2 - 8034915
AN - SCOPUS:0028205613
VL - 18
SP - 206
EP - 209
JO - Journal of Clinical Gastroenterology
JF - Journal of Clinical Gastroenterology
SN - 0192-0790
IS - 3
ER -