TY - JOUR
T1 - Hepatitis C and alcohol
AU - Schiff, E. R.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1997
Y1 - 1997
N2 - Chronic alcoholism in patients with chronic hepatitis C appears to cause more severe and rapidly progressive liver disease leading more frequently to cirrhosis of the liver and hepatocellular carcinoma. The primary risk factor for acquiring hepatitis C among alcoholics is injection drug use. However, the epidemiology is not well defined, and other sources of spread must be important. Alcohol intake in excess of 10 g/d has been associated with increased serum hepatitis C vital RNA and aminotransferase levels, the mechanism of which is poorly understood. The histological picture of hepatitis C in patients with chronic alcoholism is typically indistinguishable from chronic hepatitis C in nonalcoholic patients. Interferon therapy is less effective among alcoholic than non-alcoholic patients, even after a period of abstinence. Patients with chronic hepatitis C should restrict their alcohol intake to less than 10 g/d, and if cirrhosis is present or interferon therapy is planned, abstinence from alcohol should be encouraged. Future research efforts should focus on the epidemiology and pathogenesis of combined chronic hepatitis C and alcoholism.
AB - Chronic alcoholism in patients with chronic hepatitis C appears to cause more severe and rapidly progressive liver disease leading more frequently to cirrhosis of the liver and hepatocellular carcinoma. The primary risk factor for acquiring hepatitis C among alcoholics is injection drug use. However, the epidemiology is not well defined, and other sources of spread must be important. Alcohol intake in excess of 10 g/d has been associated with increased serum hepatitis C vital RNA and aminotransferase levels, the mechanism of which is poorly understood. The histological picture of hepatitis C in patients with chronic alcoholism is typically indistinguishable from chronic hepatitis C in nonalcoholic patients. Interferon therapy is less effective among alcoholic than non-alcoholic patients, even after a period of abstinence. Patients with chronic hepatitis C should restrict their alcohol intake to less than 10 g/d, and if cirrhosis is present or interferon therapy is planned, abstinence from alcohol should be encouraged. Future research efforts should focus on the epidemiology and pathogenesis of combined chronic hepatitis C and alcoholism.
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U2 - 10.1002/hep.510260707
DO - 10.1002/hep.510260707
M3 - Article
C2 - 9305662
AN - SCOPUS:0030931554
VL - 26
SP - 39S-42S
JO - Hepatology
JF - Hepatology
SN - 0270-9139
IS - 3 SUPPL.
ER -