Hepatitis B virus infection in hemodialysis

Recent discoveries

Fabrizio Fabrizi, Giovanna Lunghi, Paul Martin

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Controlling the spread of HBV infection in dialysis units has been one of the major advances in the treatment of patients with ESRD. The frequency of HBsAg carriers on maintenance dialysis is low in developed countries. However, prevalence and incidence rates of HBV infection among dialysis patients in less developed countries remain very high. Patients on maintenance dialysis and chronic HBsAg carriage are typically anicteric and rarely develop symptoms of hepatitis. The relationship between HBsAg and aminotransferase activity in dialysis population is stronger than has so far been recognized. HBsAg positivity is significantly associated with hepatocellular damage in dialysis patients. Aminotransferase activity in dialysis population is usually depressed; this hampers the recognition of HBV-related liver disease among dialysis patients by biochemical tests. The HBV viral load in HBsAg positive patients is low and stable over time; the low mortality attributable to liver disease in dialysis patients could be related to this finding. Numerous assays for detecting HBV DNA in serum of dialysis patients are available; they should not be used for purposes of routine screening within dialysis units. Continued implementation of the long-recommended infection control procedures against HBV within dialysis units is strongly suggested.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalJournal of Nephrology
Volume15
Issue number5
StatePublished - Sep 1 2002
Externally publishedYes

Fingerprint

Virus Diseases
Hepatitis B virus
Renal Dialysis
Dialysis
Hepatitis B Surface Antigens
Transaminases
Liver Diseases
Maintenance
Infection Control
Infection
Viral Load
Developed Countries
Hepatitis
Population
Developing Countries
Chronic Kidney Failure

Keywords

  • Aminotransferase activity
  • Dialysis
  • HBV viremia
  • Hepatitis B virus

ASJC Scopus subject areas

  • Nephrology

Cite this

Hepatitis B virus infection in hemodialysis : Recent discoveries. / Fabrizi, Fabrizio; Lunghi, Giovanna; Martin, Paul.

In: Journal of Nephrology, Vol. 15, No. 5, 01.09.2002, p. 463-468.

Research output: Contribution to journalArticle

Fabrizi, Fabrizio ; Lunghi, Giovanna ; Martin, Paul. / Hepatitis B virus infection in hemodialysis : Recent discoveries. In: Journal of Nephrology. 2002 ; Vol. 15, No. 5. pp. 463-468.
@article{281b02cf4b7f40d6b76a45733aea2bac,
title = "Hepatitis B virus infection in hemodialysis: Recent discoveries",
abstract = "Controlling the spread of HBV infection in dialysis units has been one of the major advances in the treatment of patients with ESRD. The frequency of HBsAg carriers on maintenance dialysis is low in developed countries. However, prevalence and incidence rates of HBV infection among dialysis patients in less developed countries remain very high. Patients on maintenance dialysis and chronic HBsAg carriage are typically anicteric and rarely develop symptoms of hepatitis. The relationship between HBsAg and aminotransferase activity in dialysis population is stronger than has so far been recognized. HBsAg positivity is significantly associated with hepatocellular damage in dialysis patients. Aminotransferase activity in dialysis population is usually depressed; this hampers the recognition of HBV-related liver disease among dialysis patients by biochemical tests. The HBV viral load in HBsAg positive patients is low and stable over time; the low mortality attributable to liver disease in dialysis patients could be related to this finding. Numerous assays for detecting HBV DNA in serum of dialysis patients are available; they should not be used for purposes of routine screening within dialysis units. Continued implementation of the long-recommended infection control procedures against HBV within dialysis units is strongly suggested.",
keywords = "Aminotransferase activity, Dialysis, HBV viremia, Hepatitis B virus",
author = "Fabrizio Fabrizi and Giovanna Lunghi and Paul Martin",
year = "2002",
month = "9",
day = "1",
language = "English",
volume = "15",
pages = "463--468",
journal = "Journal of Nephrology",
issn = "1121-8428",
publisher = "Wichtig Publishing",
number = "5",

}

TY - JOUR

T1 - Hepatitis B virus infection in hemodialysis

T2 - Recent discoveries

AU - Fabrizi, Fabrizio

AU - Lunghi, Giovanna

AU - Martin, Paul

PY - 2002/9/1

Y1 - 2002/9/1

N2 - Controlling the spread of HBV infection in dialysis units has been one of the major advances in the treatment of patients with ESRD. The frequency of HBsAg carriers on maintenance dialysis is low in developed countries. However, prevalence and incidence rates of HBV infection among dialysis patients in less developed countries remain very high. Patients on maintenance dialysis and chronic HBsAg carriage are typically anicteric and rarely develop symptoms of hepatitis. The relationship between HBsAg and aminotransferase activity in dialysis population is stronger than has so far been recognized. HBsAg positivity is significantly associated with hepatocellular damage in dialysis patients. Aminotransferase activity in dialysis population is usually depressed; this hampers the recognition of HBV-related liver disease among dialysis patients by biochemical tests. The HBV viral load in HBsAg positive patients is low and stable over time; the low mortality attributable to liver disease in dialysis patients could be related to this finding. Numerous assays for detecting HBV DNA in serum of dialysis patients are available; they should not be used for purposes of routine screening within dialysis units. Continued implementation of the long-recommended infection control procedures against HBV within dialysis units is strongly suggested.

AB - Controlling the spread of HBV infection in dialysis units has been one of the major advances in the treatment of patients with ESRD. The frequency of HBsAg carriers on maintenance dialysis is low in developed countries. However, prevalence and incidence rates of HBV infection among dialysis patients in less developed countries remain very high. Patients on maintenance dialysis and chronic HBsAg carriage are typically anicteric and rarely develop symptoms of hepatitis. The relationship between HBsAg and aminotransferase activity in dialysis population is stronger than has so far been recognized. HBsAg positivity is significantly associated with hepatocellular damage in dialysis patients. Aminotransferase activity in dialysis population is usually depressed; this hampers the recognition of HBV-related liver disease among dialysis patients by biochemical tests. The HBV viral load in HBsAg positive patients is low and stable over time; the low mortality attributable to liver disease in dialysis patients could be related to this finding. Numerous assays for detecting HBV DNA in serum of dialysis patients are available; they should not be used for purposes of routine screening within dialysis units. Continued implementation of the long-recommended infection control procedures against HBV within dialysis units is strongly suggested.

KW - Aminotransferase activity

KW - Dialysis

KW - HBV viremia

KW - Hepatitis B virus

UR - http://www.scopus.com/inward/record.url?scp=0036760236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036760236&partnerID=8YFLogxK

M3 - Article

VL - 15

SP - 463

EP - 468

JO - Journal of Nephrology

JF - Journal of Nephrology

SN - 1121-8428

IS - 5

ER -