HEPATITIS-ASSOCIATED ANTIGEN IN UGANDAN PATIENTS WITH HEPATOCELLULAR CARCINOMA

Charles L. Vogel, Natu Mody, Peter P. Anthony, Lewellys F. Barker

Research output: Contribution to journalArticle

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Abstract

18 of 45 (40%) Ugandan patients with Shepatocellular carcinoma and 4 of 122 (3%) control patients had positive complement-fixation tests for hepatitis-associated antigen (H.A.A.). There was a tendency for H.A.A.-positive individuals with hepatocellular carcinoma to be α-fetoprotein positive and to have underlying cirrhosis of the "posthepatitic" type. Young patients tended to be H.A.A. positive more frequently than old patients. The data provide support for the hypothesis that antecedent viral-hepatitis infection may play some role in the ætiology and pathogenesis of hepatocellular carcinoma in Uganda.

Original languageEnglish (US)
Pages (from-to)621-624
Number of pages4
JournalThe Lancet
Volume296
Issue number7674
DOIs
StatePublished - Sep 26 1970

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ASJC Scopus subject areas

  • Medicine(all)

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