HEPATITIS-ASSOCIATED ANTIGEN IN UGANDAN PATIENTS WITH HEPATOCELLULAR CARCINOMA

Charles Vogel, Natu Mody, PeterP Anthony, LewellysF Barker

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

18 of 45 (40%) Ugandan patients with Shepatocellular carcinoma and 4 of 122 (3%) control patients had positive complement-fixation tests for hepatitis-associated antigen (H.A.A.). There was a tendency for H.A.A.-positive individuals with hepatocellular carcinoma to be α-fetoprotein positive and to have underlying cirrhosis of the "posthepatitic" type. Young patients tended to be H.A.A. positive more frequently than old patients. The data provide support for the hypothesis that antecedent viral-hepatitis infection may play some role in the ætiology and pathogenesis of hepatocellular carcinoma in Uganda.

Original languageEnglish (US)
Pages (from-to)621-624
Number of pages4
JournalThe Lancet
Volume296
Issue number7674
DOIs
StatePublished - Sep 26 1970
Externally publishedYes

Fingerprint

Hepatitis Antigens
Hepatocellular Carcinoma
Fetal Proteins
Complement Fixation Tests
Hepatitis B e Antigens
Uganda
Virus Diseases
Hepatitis
Fibrosis
Carcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

HEPATITIS-ASSOCIATED ANTIGEN IN UGANDAN PATIENTS WITH HEPATOCELLULAR CARCINOMA. / Vogel, Charles; Mody, Natu; Anthony, PeterP; Barker, LewellysF.

In: The Lancet, Vol. 296, No. 7674, 26.09.1970, p. 621-624.

Research output: Contribution to journalArticle

Vogel, Charles ; Mody, Natu ; Anthony, PeterP ; Barker, LewellysF. / HEPATITIS-ASSOCIATED ANTIGEN IN UGANDAN PATIENTS WITH HEPATOCELLULAR CARCINOMA. In: The Lancet. 1970 ; Vol. 296, No. 7674. pp. 621-624.
@article{2a13cf436000436983b08b4ec0c035ef,
title = "HEPATITIS-ASSOCIATED ANTIGEN IN UGANDAN PATIENTS WITH HEPATOCELLULAR CARCINOMA",
abstract = "18 of 45 (40{\%}) Ugandan patients with Shepatocellular carcinoma and 4 of 122 (3{\%}) control patients had positive complement-fixation tests for hepatitis-associated antigen (H.A.A.). There was a tendency for H.A.A.-positive individuals with hepatocellular carcinoma to be α-fetoprotein positive and to have underlying cirrhosis of the {"}posthepatitic{"} type. Young patients tended to be H.A.A. positive more frequently than old patients. The data provide support for the hypothesis that antecedent viral-hepatitis infection may play some role in the {\ae}tiology and pathogenesis of hepatocellular carcinoma in Uganda.",
author = "Charles Vogel and Natu Mody and PeterP Anthony and LewellysF Barker",
year = "1970",
month = "9",
day = "26",
doi = "10.1016/S0140-6736(70)91396-6",
language = "English (US)",
volume = "296",
pages = "621--624",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "7674",

}

TY - JOUR

T1 - HEPATITIS-ASSOCIATED ANTIGEN IN UGANDAN PATIENTS WITH HEPATOCELLULAR CARCINOMA

AU - Vogel, Charles

AU - Mody, Natu

AU - Anthony, PeterP

AU - Barker, LewellysF

PY - 1970/9/26

Y1 - 1970/9/26

N2 - 18 of 45 (40%) Ugandan patients with Shepatocellular carcinoma and 4 of 122 (3%) control patients had positive complement-fixation tests for hepatitis-associated antigen (H.A.A.). There was a tendency for H.A.A.-positive individuals with hepatocellular carcinoma to be α-fetoprotein positive and to have underlying cirrhosis of the "posthepatitic" type. Young patients tended to be H.A.A. positive more frequently than old patients. The data provide support for the hypothesis that antecedent viral-hepatitis infection may play some role in the ætiology and pathogenesis of hepatocellular carcinoma in Uganda.

AB - 18 of 45 (40%) Ugandan patients with Shepatocellular carcinoma and 4 of 122 (3%) control patients had positive complement-fixation tests for hepatitis-associated antigen (H.A.A.). There was a tendency for H.A.A.-positive individuals with hepatocellular carcinoma to be α-fetoprotein positive and to have underlying cirrhosis of the "posthepatitic" type. Young patients tended to be H.A.A. positive more frequently than old patients. The data provide support for the hypothesis that antecedent viral-hepatitis infection may play some role in the ætiology and pathogenesis of hepatocellular carcinoma in Uganda.

UR - http://www.scopus.com/inward/record.url?scp=0014963681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014963681&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(70)91396-6

DO - 10.1016/S0140-6736(70)91396-6

M3 - Article

C2 - 4195767

AN - SCOPUS:0014963681

VL - 296

SP - 621

EP - 624

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 7674

ER -