Hepatitis-associated antigen and antibody in hepatocellular carcinoma: Results of a continuing study23

Charles L. Vogel, Peter P. Anthony, F. Sadikali, Lewellys F. Barker, Michael R. Peterson

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Tests for hepatitis-associated antigen (HAA) and antibody to HAA (anti-HAA) were done on sera from 90 Ugandan patients with hepatocellular carcinoma and 224 controls. While the frequency of anti-HAA did not differ between the 2 groups, the frequency of persistent HAA infection was significantly greater in the hepatocellular carcinoma patients than in controls. Alpha fetoprotein (AFP)-positive patients with hepatocellular carcinoma were HAA positive significantly more often than AFP-negative patients. Although the etiologic implications of these findings are speculative, the data support the hypothesis that viral hepatitis infection is a factor in the ultimate development of hepatocellular carcinoma in Ugandan patients.

Original languageEnglish (US)
Pages (from-to)1583-1588
Number of pages6
JournalJournal of the National Cancer Institute
Volume48
Issue number6
DOIs
StatePublished - Jun 1972
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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