Hepatic lesions in Syrian golden hamsters with pancreatic carcinoma induced by N-nitrosobis(2-oxopropyl)amine (BOP).

A. Zalatnai, Andrew V Schally

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hepatic lesions in 25 male and 24 female Syrian golden hamsters with N-Nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic cancer have been studied. Although BOP produced pancreatic cancer in 100% of the animals, its hepatocarcinogenic potential proved to be very weak, only occasional preneoplastic foci, neoplastic nodules and hepatocellular carcinoma developed. However, a broad spectrum of mainly proliferative, non-neoplastic alterations were found in the liver. The major site of alterations was the portal space, especially the biliary ducts were affected: bile duct hyperplasia, oval cell proliferation and formation of biliary cysts were the most frequently encountered changes. In the large ducts of the female hamsters a goblet cell metaplasia occurred, but the male animals were devoid of this lesion. Our results demonstrate that although the BOP is considered as a selective pancreatotropic nitrosamine derivate, it may cause various proliferative changes in the biliary duct system of hamsters.

Original languageEnglish
Pages (from-to)119-130
Number of pages12
JournalActa Morphologica Hungarica
Volume38
Issue number2
StatePublished - Dec 1 1990
Externally publishedYes

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nitrosobis(2-oxopropyl)amine
Mesocricetus
Pancreatic Neoplasms
Cricetinae
Nitrosamines
Goblet Cells
Liver
Metaplasia
Biliary Tract
Bile Ducts
Hyperplasia
Cysts
Hepatocellular Carcinoma
Cell Proliferation
Pancreatic Carcinoma

ASJC Scopus subject areas

  • Anatomy

Cite this

Hepatic lesions in Syrian golden hamsters with pancreatic carcinoma induced by N-nitrosobis(2-oxopropyl)amine (BOP). / Zalatnai, A.; Schally, Andrew V.

In: Acta Morphologica Hungarica, Vol. 38, No. 2, 01.12.1990, p. 119-130.

Research output: Contribution to journalArticle

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