Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C

John K. Olynyk, K. Rajender Reddy, Adrian M. Di Bisceglie, Lennox J Jeffers, Talley I. Parker, Jason L. Radick, Eugene R Schiff, Bruce R. Bacon

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Abstract

Background/Aims: It has been reported that hepatic iron concentration (HIC) may influence response to therapy in chronic viral hepatitis. The aim of this study was to determine the relationship between HIC and response to interferon alfa therapy in patients with chronic hepatitis C. Methods: HIC was measured in liver biopsy specimens from 58 patients with chronic hepatitis C treated at three centers. Three patients had mild chronic hepatitis C, 35 had moderate to severe chronic hepatitis C, and 20 had active cirrhosis. Serum ferritin levels were measured in 51 of these 58 patients. Response to therapy was defined as normalization of alanine aminotransferase levels at the end of treatment. Results: Twenty-four patients (41%) responded to therapy. HICs were generally within the normal range (<1500 μg/g). The mean HIC in nonresponders (860 ± 100 μg/g; range, 116-2296 μg/g) was significantly higher than in responders (548 ± 85 μg/g; range, 29-1870 μg/g) (P < 0.05). Eighty-eight percent of patients with an HIC of >1100 μg/g and 87% of patients with an elevated serum ferritin concentration did not respond to interferon alfa therapy. Conclusions: HIC seems to influence response to interferon alfa therapy among patients with chronic hepatitis C. A subgroup of patients with chronic hepatitis C has been identified for which an HIC of >1100 μg/g predicted nonresponse in 88% of patients.

Original languageEnglish
Pages (from-to)1104-1109
Number of pages6
JournalGastroenterology
Volume108
Issue number4
DOIs
StatePublished - Apr 5 1995

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Chronic Hepatitis C
Interferon-alpha
Iron
Liver
Therapeutics
Ferritins
Chronic Hepatitis
Serum
Alanine Transaminase
Reference Values
Fibrosis
Biopsy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Olynyk, J. K., Rajender Reddy, K., Di Bisceglie, A. M., Jeffers, L. J., Parker, T. I., Radick, J. L., ... Bacon, B. R. (1995). Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C. Gastroenterology, 108(4), 1104-1109. https://doi.org/10.1016/0016-5085(95)90209-0

Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C. / Olynyk, John K.; Rajender Reddy, K.; Di Bisceglie, Adrian M.; Jeffers, Lennox J; Parker, Talley I.; Radick, Jason L.; Schiff, Eugene R; Bacon, Bruce R.

In: Gastroenterology, Vol. 108, No. 4, 05.04.1995, p. 1104-1109.

Research output: Contribution to journalArticle

Olynyk, JK, Rajender Reddy, K, Di Bisceglie, AM, Jeffers, LJ, Parker, TI, Radick, JL, Schiff, ER & Bacon, BR 1995, 'Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C', Gastroenterology, vol. 108, no. 4, pp. 1104-1109. https://doi.org/10.1016/0016-5085(95)90209-0
Olynyk JK, Rajender Reddy K, Di Bisceglie AM, Jeffers LJ, Parker TI, Radick JL et al. Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C. Gastroenterology. 1995 Apr 5;108(4):1104-1109. https://doi.org/10.1016/0016-5085(95)90209-0
Olynyk, John K. ; Rajender Reddy, K. ; Di Bisceglie, Adrian M. ; Jeffers, Lennox J ; Parker, Talley I. ; Radick, Jason L. ; Schiff, Eugene R ; Bacon, Bruce R. / Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C. In: Gastroenterology. 1995 ; Vol. 108, No. 4. pp. 1104-1109.
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abstract = "Background/Aims: It has been reported that hepatic iron concentration (HIC) may influence response to therapy in chronic viral hepatitis. The aim of this study was to determine the relationship between HIC and response to interferon alfa therapy in patients with chronic hepatitis C. Methods: HIC was measured in liver biopsy specimens from 58 patients with chronic hepatitis C treated at three centers. Three patients had mild chronic hepatitis C, 35 had moderate to severe chronic hepatitis C, and 20 had active cirrhosis. Serum ferritin levels were measured in 51 of these 58 patients. Response to therapy was defined as normalization of alanine aminotransferase levels at the end of treatment. Results: Twenty-four patients (41{\%}) responded to therapy. HICs were generally within the normal range (<1500 μg/g). The mean HIC in nonresponders (860 ± 100 μg/g; range, 116-2296 μg/g) was significantly higher than in responders (548 ± 85 μg/g; range, 29-1870 μg/g) (P < 0.05). Eighty-eight percent of patients with an HIC of >1100 μg/g and 87{\%} of patients with an elevated serum ferritin concentration did not respond to interferon alfa therapy. Conclusions: HIC seems to influence response to interferon alfa therapy among patients with chronic hepatitis C. A subgroup of patients with chronic hepatitis C has been identified for which an HIC of >1100 μg/g predicted nonresponse in 88{\%} of patients.",
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