Hepatic cytomembranous inclusions in patients with type C chronic hepatitis

Seishiro Watanabe, Mutsunori Shirai, Keiji Arima, Mikio Nishioka, Miyuki Ohbayashi, Eugene R Schiff

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Electron microscopic studies of the liver biopsy specimens from two patients with chronic type C hepatitis revealed cytomembranous structures. Cylindrical confronting cisternae were identified for the first time in the cytoplasm of macrophages in the specimen which was taken during α-interferon therapy. Tubuloreticular inclusions were observed in both patients with and without therapy. Although the cytomembranous inclusions are not specific for hepatitis C patients, cylindrical confronting cisternae may be a host response to both large doses of α-interferon and HCV infection.

Original languageEnglish
Pages (from-to)190-195
Number of pages6
JournalInternational Hepatology Communications
Volume3
Issue number4
DOIs
StatePublished - Jan 1 1995

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Chronic Hepatitis C
Interferons
Liver
Hepatitis C
Cytoplasm
Macrophages
Electrons
Biopsy
Therapeutics
Infection

Keywords

  • Chronic type C hepatitis
  • Cylindrical confronting cisternae
  • Tubuloreticular inclusions
  • α-interferon therapy

ASJC Scopus subject areas

  • Hepatology

Cite this

Hepatic cytomembranous inclusions in patients with type C chronic hepatitis. / Watanabe, Seishiro; Shirai, Mutsunori; Arima, Keiji; Nishioka, Mikio; Ohbayashi, Miyuki; Schiff, Eugene R.

In: International Hepatology Communications, Vol. 3, No. 4, 01.01.1995, p. 190-195.

Research output: Contribution to journalArticle

Watanabe, Seishiro ; Shirai, Mutsunori ; Arima, Keiji ; Nishioka, Mikio ; Ohbayashi, Miyuki ; Schiff, Eugene R. / Hepatic cytomembranous inclusions in patients with type C chronic hepatitis. In: International Hepatology Communications. 1995 ; Vol. 3, No. 4. pp. 190-195.
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