Electron microscopic studies of the liver biopsy specimens from two patients with chronic type C hepatitis revealed cytomembranous structures. Cylindrical confronting cisternae were identified for the first time in the cytoplasm of macrophages in the specimen which was taken during α-interferon therapy. Tubuloreticular inclusions were observed in both patients with and without therapy. Although the cytomembranous inclusions are not specific for hepatitis C patients, cylindrical confronting cisternae may be a host response to both large doses of α-interferon and HCV infection.
- Chronic type C hepatitis
- Cylindrical confronting cisternae
- Tubuloreticular inclusions
- α-interferon therapy
ASJC Scopus subject areas