Hepatic cytomembranous inclusions in patients with type C chronic hepatitis

Seishiro Watanabe, Mutsunori Shirai, Keiji Arima, Mikio Nishioka, Miyuki Ohbayashi, Eugene R. Schiff

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Electron microscopic studies of the liver biopsy specimens from two patients with chronic type C hepatitis revealed cytomembranous structures. Cylindrical confronting cisternae were identified for the first time in the cytoplasm of macrophages in the specimen which was taken during α-interferon therapy. Tubuloreticular inclusions were observed in both patients with and without therapy. Although the cytomembranous inclusions are not specific for hepatitis C patients, cylindrical confronting cisternae may be a host response to both large doses of α-interferon and HCV infection.

Original languageEnglish (US)
Pages (from-to)190-195
Number of pages6
JournalInternational Hepatology Communications
Issue number4
StatePublished - Apr 1995


  • Chronic type C hepatitis
  • Cylindrical confronting cisternae
  • Tubuloreticular inclusions
  • α-interferon therapy

ASJC Scopus subject areas

  • Hepatology


Dive into the research topics of 'Hepatic cytomembranous inclusions in patients with type C chronic hepatitis'. Together they form a unique fingerprint.

Cite this