Hepatic adenomata with type 1 glycogen storage disease.

R. Howell, R. E. Stevenson, Y. Ben-Menachem, R. L. Phyliky, D. H. Berry

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

In older patients with glucose-6-phosphatase deficiency adenomatous nodules develop within the liver parenchyma. Investigation of eight such patients, age 3 to 28 years, using radioisotopic scans, has demonstrated areas of depressed isotope uptake in the liver in all except the one preteenaged child. Three patients were further studied with hepatic angiograms and liver biopsy specimens. A diffuse nodularity, more widespread than apparent on isotopic scans, was demonstrated on angiograms. Although initial histologic study in each case showed adenomatous tissue without evidence of neoplasm, the development of hepatocellular carcinoma in one of our patients and in others from the literature suggests that the nodules may be premalignant.

Original languageEnglish
Pages (from-to)1481-1484
Number of pages4
JournalJournal of the American Medical Association
Volume236
Issue number13
DOIs
StatePublished - Sep 27 1976
Externally publishedYes

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Glycogen Storage Disease Type I
Adenoma
Liver
Angiography
Isotopes
Hepatocellular Carcinoma
Biopsy
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Howell, R., Stevenson, R. E., Ben-Menachem, Y., Phyliky, R. L., & Berry, D. H. (1976). Hepatic adenomata with type 1 glycogen storage disease. Journal of the American Medical Association, 236(13), 1481-1484. https://doi.org/10.1001/jama.236.13.1481

Hepatic adenomata with type 1 glycogen storage disease. / Howell, R.; Stevenson, R. E.; Ben-Menachem, Y.; Phyliky, R. L.; Berry, D. H.

In: Journal of the American Medical Association, Vol. 236, No. 13, 27.09.1976, p. 1481-1484.

Research output: Contribution to journalArticle

Howell, R, Stevenson, RE, Ben-Menachem, Y, Phyliky, RL & Berry, DH 1976, 'Hepatic adenomata with type 1 glycogen storage disease.', Journal of the American Medical Association, vol. 236, no. 13, pp. 1481-1484. https://doi.org/10.1001/jama.236.13.1481
Howell, R. ; Stevenson, R. E. ; Ben-Menachem, Y. ; Phyliky, R. L. ; Berry, D. H. / Hepatic adenomata with type 1 glycogen storage disease. In: Journal of the American Medical Association. 1976 ; Vol. 236, No. 13. pp. 1481-1484.
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