Heparin inhibits IP3-induced Ca2+ release in permeabilized pancreatic β-cells

Thomas Nilsson; Jean Zwiller; Alton L. Boynton; Per Olof Berggren

doi:10.1016/0014-5793(88)80829-9

Heparin inhibits IP₃-induced Ca²⁺ release in permeabilized pancreatic β-cells

Thomas Nilsson, Jean Zwiller, Alton L. Boynton, Per Olof Berggren

Research output: Contribution to journal › Article

45 Citations (Scopus)

Abstract

Heparin was found to inhibit the Ca²⁺ release induced by inositol 1,4,5-trisphosphate (IP₃) in permeabilized pancreatic β-cells obtained from obese hyperglycemic mice. The effect of heparin was dose-dependent and not due to inhibition of Ca²⁺ uptake into the IP₃-sensitive pool. The effect appeared specific for heparin and was not reproduced by other polysaccharides such as chondroitin sulfates. Heparin might consequently be a useful tool when investigating the molecular mechanism whereby IP₃ mobilizes Ca²⁺.

Original language	English
Pages (from-to)	211-214
Number of pages	4
Journal	FEBS Letters
Volume	229
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(88)80829-9
State	Published - Feb 29 1988
Externally published	Yes

Fingerprint

Heparin

Obese Mice

Inositol 1,4,5-Trisphosphate

Chondroitin Sulfates

Polysaccharides

Keywords

(Permeabilized pancreatic β-cell)
Ca release
Heparin
Inositol 1,3,4,5-tetrakisphosphate
Inositol 1,4,5-trisphosphate

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

Cite this

Nilsson, T., Zwiller, J., Boynton, A. L., & Berggren, P. O. (1988). Heparin inhibits IP₃-induced Ca²⁺ release in permeabilized pancreatic β-cells. FEBS Letters, 229(1), 211-214. https://doi.org/10.1016/0014-5793(88)80829-9

Heparin inhibits IP₃-induced Ca²⁺ release in permeabilized pancreatic β-cells. / Nilsson, Thomas; Zwiller, Jean; Boynton, Alton L.; Berggren, Per Olof.

In: FEBS Letters, Vol. 229, No. 1, 29.02.1988, p. 211-214.

Research output: Contribution to journal › Article

Nilsson, T, Zwiller, J, Boynton, AL & Berggren, PO 1988, 'Heparin inhibits IP₃-induced Ca²⁺ release in permeabilized pancreatic β-cells', FEBS Letters, vol. 229, no. 1, pp. 211-214. https://doi.org/10.1016/0014-5793(88)80829-9

Nilsson T, Zwiller J, Boynton AL, Berggren PO. Heparin inhibits IP₃-induced Ca²⁺ release in permeabilized pancreatic β-cells. FEBS Letters. 1988 Feb 29;229(1):211-214. https://doi.org/10.1016/0014-5793(88)80829-9

Nilsson, Thomas ; Zwiller, Jean ; Boynton, Alton L. ; Berggren, Per Olof. / Heparin inhibits IP₃-induced Ca²⁺ release in permeabilized pancreatic β-cells. In: FEBS Letters. 1988 ; Vol. 229, No. 1. pp. 211-214.

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Access to Document

10.1016/0014-5793(88)80829-9