Heparin inhibits IP3-induced Ca2+ release in permeabilized pancreatic β-cells

Thomas Nilsson, Jean Zwiller, Alton L. Boynton, Per Olof Berggren

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Heparin was found to inhibit the Ca2+ release induced by inositol 1,4,5-trisphosphate (IP3) in permeabilized pancreatic β-cells obtained from obese hyperglycemic mice. The effect of heparin was dose-dependent and not due to inhibition of Ca2+ uptake into the IP3-sensitive pool. The effect appeared specific for heparin and was not reproduced by other polysaccharides such as chondroitin sulfates. Heparin might consequently be a useful tool when investigating the molecular mechanism whereby IP3 mobilizes Ca2+.

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalFEBS letters
Volume229
Issue number1
DOIs
StatePublished - Feb 29 1988

Keywords

  • (Permeabilized pancreatic β-cell)
  • Ca release
  • Heparin
  • Inositol 1,3,4,5-tetrakisphosphate
  • Inositol 1,4,5-trisphosphate

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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