Heparin inhibits IP3-induced Ca2+ release in permeabilized pancreatic β-cells

Thomas Nilsson, Jean Zwiller, Alton L. Boynton, Per Olof Berggren

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Heparin was found to inhibit the Ca2+ release induced by inositol 1,4,5-trisphosphate (IP3) in permeabilized pancreatic β-cells obtained from obese hyperglycemic mice. The effect of heparin was dose-dependent and not due to inhibition of Ca2+ uptake into the IP3-sensitive pool. The effect appeared specific for heparin and was not reproduced by other polysaccharides such as chondroitin sulfates. Heparin might consequently be a useful tool when investigating the molecular mechanism whereby IP3 mobilizes Ca2+.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalFEBS Letters
Volume229
Issue number1
DOIs
StatePublished - Feb 29 1988
Externally publishedYes

Fingerprint

Heparin
Obese Mice
Inositol 1,4,5-Trisphosphate
Chondroitin Sulfates
Polysaccharides

Keywords

  • (Permeabilized pancreatic β-cell)
  • Ca release
  • Heparin
  • Inositol 1,3,4,5-tetrakisphosphate
  • Inositol 1,4,5-trisphosphate

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Heparin inhibits IP3-induced Ca2+ release in permeabilized pancreatic β-cells. / Nilsson, Thomas; Zwiller, Jean; Boynton, Alton L.; Berggren, Per Olof.

In: FEBS Letters, Vol. 229, No. 1, 29.02.1988, p. 211-214.

Research output: Contribution to journalArticle

Nilsson, T, Zwiller, J, Boynton, AL & Berggren, PO 1988, 'Heparin inhibits IP3-induced Ca2+ release in permeabilized pancreatic β-cells', FEBS Letters, vol. 229, no. 1, pp. 211-214. https://doi.org/10.1016/0014-5793(88)80829-9
Nilsson, Thomas ; Zwiller, Jean ; Boynton, Alton L. ; Berggren, Per Olof. / Heparin inhibits IP3-induced Ca2+ release in permeabilized pancreatic β-cells. In: FEBS Letters. 1988 ; Vol. 229, No. 1. pp. 211-214.
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