Abstract
Heparin was found to inhibit the Ca2+ release induced by inositol 1,4,5-trisphosphate (IP3) in permeabilized pancreatic β-cells obtained from obese hyperglycemic mice. The effect of heparin was dose-dependent and not due to inhibition of Ca2+ uptake into the IP3-sensitive pool. The effect appeared specific for heparin and was not reproduced by other polysaccharides such as chondroitin sulfates. Heparin might consequently be a useful tool when investigating the molecular mechanism whereby IP3 mobilizes Ca2+.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 211-214 |
| Number of pages | 4 |
| Journal | FEBS letters |
| Volume | 229 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 29 1988 |
Keywords
- (Permeabilized pancreatic β-cell)
- Ca release
- Heparin
- Inositol 1,3,4,5-tetrakisphosphate
- Inositol 1,4,5-trisphosphate
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Nilsson, T., Zwiller, J., Boynton, A. L., & Berggren, P. O. (1988). Heparin inhibits IP3-induced Ca2+ release in permeabilized pancreatic β-cells. FEBS letters, 229(1), 211-214. https://doi.org/10.1016/0014-5793(88)80829-9