Heparin and sodium hyaluronate effects on implantation of an artificial meshwork (MESH)

H. Kondo, J. M. Parel, H. Kato

Research output: Contribution to journalArticlepeer-review


Purpose. The MESH was shown to be an efficacious glaucoma filtration implant in the rabbit (8 animals, 3 months study, IOVS 36:S412, 1995). We modified the procedure using heparin and sodium hyaluronate (HA). Methods. Fifteen eyes of 15 rabbits were implanted with a 3 x 6mm MESH (PTFE, 10μm pores): 6 received a MESH (group I); 6 a MESH soaked with heparin to inhibit intraocular fibrin formation (group II); 3 received HA in the anterior chamber prior implantation to maintain the chamber depth, minimize tissue injury and prevent tissue adhesion to the MESH (group III). IOP (Goldmann) and outflow (Shiötz) in both eyes were assessed weekly. Results. Statistically, all groups had the same IOP reduction and increased outflow as in our previous study. Fibrin formation and tissue adhesion effects were clinically similar in all groups. (Graph Presented) Conclusions. The MESH should be implanted with a minimum amount of surgical stress but heparin and HA seem to offer little, if any, clinical advantages. In the rabbit, the MESH seems more efficacious than trabeculectomy with adjunct mitomycin (Arch Ophthalmol 109:1725,1991).

Original languageEnglish (US)
Pages (from-to)S256
JournalInvestigative Ophthalmology and Visual Science
Issue number3
StatePublished - Feb 15 1996

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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