Hemophagocytic lymphohistiocytosis in systemic mastocytosis treated with allogeneic bone marrow transplant: A case report

Anand Srinivasan, Chibuzo C. Ilonze, Stephen R. Travis, David Crawford

Research output: Contribution to journalArticlepeer-review

Abstract

Systemic mastocytosis is a rare entity in pediatrics, usually associated with mutations in the c-KIT gene. We describe a Caucasian female who presented with severe systemic mastocytosis with food allergies requiring prolonged total parenteral nutrition. Her course was further complicated by the onset of hemophagocytic lymphohistiocytosis, which responded poorly to conventional chemotherapy. She underwent an allogeneic hematopoietic stem cell transplant that resulted in resolution of all symptoms related to systemic mastocytosis and hemophagocytic lymphohistiocytosis. She is now disease-free and without any complications two years after the transplant.

Original languageEnglish (US)
Article numbere28017
JournalPediatric Blood and Cancer
Volume67
Issue number1
DOIs
StatePublished - Jan 1 2020
Externally publishedYes

Keywords

  • hemophagocytic lymphohistiocytosis
  • pediatric allogeneic transplant
  • systemic mastocytosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Fingerprint

Dive into the research topics of 'Hemophagocytic lymphohistiocytosis in systemic mastocytosis treated with allogeneic bone marrow transplant: A case report'. Together they form a unique fingerprint.

Cite this