Hemodynamics associated with breathing through an inspiratory impedance threshold device in human volunteers.

Victor A. Convertino, Duane A. Ratliff, Kathy L. Ryan, Donald F. Doerr, David Ludwig, Gary W. Muniz, Deanna L. Britton, Savran D. Clah, Kathleen B. Fernald, Alicia F. Ruiz, Keith G. Lurie, Ahamed H. Idris

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

OBJECTIVE: Increased negative intrathoracic pressure during spontaneous inspiration through an impedance threshold device (ITD) causes elevated arterial blood pressure in humans. This study was performed to determine whether the acute increase in blood pressure induced by breathing through an ITD is associated with increased stroke volume and cardiac output. DESIGN: Randomized, blinded, controlled trial. SETTING: Laboratory. SUBJECTS: Ten women and ten men. INTERVENTIONS: We measured hemodynamic and respiratory responses during two separate ITD conditions: 1) breathing through a face mask with an ITD (impedance of 6 cm H2O [0.59 kPa]) and 2) breathing through the same face mask with a sham ITD (control). Stroke volume was measured by thoracic bioimpedance. MEASUREMENTS AND MAIN RESULTS: Compared with the control condition, ITD produced higher stroke volume (124 +/- 3 vs. 137 +/- 3 mL; p = .013), heart rate (63 +/- 3 vs. 68 +/- 3 beats/min; p = .049), cardiac output (7.69 vs. 9.34 L/min; p = .001), and systolic blood pressure (115 +/- 2 to 122 +/- 2 mm Hg [15.33 +/- 0.3 to 16.26 +/- 0.3 kPa]; p = .005) without affecting expired minute ventilation (6.2 +/- 0.4 to 6.5 +/- 0.4 L/min; p = .609). CONCLUSIONS: Breathing with an ITD at relatively low impedance increases systolic blood pressure by increasing stroke volume and cardiac output. The ITD may provide short-term protection against cardiovascular collapse induced by orthostatic stress or hemorrhage.

Original languageEnglish
JournalCritical Care Medicine
Volume32
Issue number9 Suppl
StatePublished - Sep 1 2004
Externally publishedYes

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Electric Impedance
Volunteers
Respiration
Hemodynamics
Equipment and Supplies
Stroke Volume
Blood Pressure
Cardiac Output
Masks
Ventilation
Arterial Pressure
Thorax
Randomized Controlled Trials
Heart Rate
Hemorrhage
Pressure

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Convertino, V. A., Ratliff, D. A., Ryan, K. L., Doerr, D. F., Ludwig, D., Muniz, G. W., ... Idris, A. H. (2004). Hemodynamics associated with breathing through an inspiratory impedance threshold device in human volunteers. Critical Care Medicine, 32(9 Suppl).

Hemodynamics associated with breathing through an inspiratory impedance threshold device in human volunteers. / Convertino, Victor A.; Ratliff, Duane A.; Ryan, Kathy L.; Doerr, Donald F.; Ludwig, David; Muniz, Gary W.; Britton, Deanna L.; Clah, Savran D.; Fernald, Kathleen B.; Ruiz, Alicia F.; Lurie, Keith G.; Idris, Ahamed H.

In: Critical Care Medicine, Vol. 32, No. 9 Suppl, 01.09.2004.

Research output: Contribution to journalArticle

Convertino, VA, Ratliff, DA, Ryan, KL, Doerr, DF, Ludwig, D, Muniz, GW, Britton, DL, Clah, SD, Fernald, KB, Ruiz, AF, Lurie, KG & Idris, AH 2004, 'Hemodynamics associated with breathing through an inspiratory impedance threshold device in human volunteers.', Critical Care Medicine, vol. 32, no. 9 Suppl.
Convertino VA, Ratliff DA, Ryan KL, Doerr DF, Ludwig D, Muniz GW et al. Hemodynamics associated with breathing through an inspiratory impedance threshold device in human volunteers. Critical Care Medicine. 2004 Sep 1;32(9 Suppl).
Convertino, Victor A. ; Ratliff, Duane A. ; Ryan, Kathy L. ; Doerr, Donald F. ; Ludwig, David ; Muniz, Gary W. ; Britton, Deanna L. ; Clah, Savran D. ; Fernald, Kathleen B. ; Ruiz, Alicia F. ; Lurie, Keith G. ; Idris, Ahamed H. / Hemodynamics associated with breathing through an inspiratory impedance threshold device in human volunteers. In: Critical Care Medicine. 2004 ; Vol. 32, No. 9 Suppl.
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abstract = "OBJECTIVE: Increased negative intrathoracic pressure during spontaneous inspiration through an impedance threshold device (ITD) causes elevated arterial blood pressure in humans. This study was performed to determine whether the acute increase in blood pressure induced by breathing through an ITD is associated with increased stroke volume and cardiac output. DESIGN: Randomized, blinded, controlled trial. SETTING: Laboratory. SUBJECTS: Ten women and ten men. INTERVENTIONS: We measured hemodynamic and respiratory responses during two separate ITD conditions: 1) breathing through a face mask with an ITD (impedance of 6 cm H2O [0.59 kPa]) and 2) breathing through the same face mask with a sham ITD (control). Stroke volume was measured by thoracic bioimpedance. MEASUREMENTS AND MAIN RESULTS: Compared with the control condition, ITD produced higher stroke volume (124 +/- 3 vs. 137 +/- 3 mL; p = .013), heart rate (63 +/- 3 vs. 68 +/- 3 beats/min; p = .049), cardiac output (7.69 vs. 9.34 L/min; p = .001), and systolic blood pressure (115 +/- 2 to 122 +/- 2 mm Hg [15.33 +/- 0.3 to 16.26 +/- 0.3 kPa]; p = .005) without affecting expired minute ventilation (6.2 +/- 0.4 to 6.5 +/- 0.4 L/min; p = .609). CONCLUSIONS: Breathing with an ITD at relatively low impedance increases systolic blood pressure by increasing stroke volume and cardiac output. The ITD may provide short-term protection against cardiovascular collapse induced by orthostatic stress or hemorrhage.",
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AU - Convertino, Victor A.

AU - Ratliff, Duane A.

AU - Ryan, Kathy L.

AU - Doerr, Donald F.

AU - Ludwig, David

AU - Muniz, Gary W.

AU - Britton, Deanna L.

AU - Clah, Savran D.

AU - Fernald, Kathleen B.

AU - Ruiz, Alicia F.

AU - Lurie, Keith G.

AU - Idris, Ahamed H.

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N2 - OBJECTIVE: Increased negative intrathoracic pressure during spontaneous inspiration through an impedance threshold device (ITD) causes elevated arterial blood pressure in humans. This study was performed to determine whether the acute increase in blood pressure induced by breathing through an ITD is associated with increased stroke volume and cardiac output. DESIGN: Randomized, blinded, controlled trial. SETTING: Laboratory. SUBJECTS: Ten women and ten men. INTERVENTIONS: We measured hemodynamic and respiratory responses during two separate ITD conditions: 1) breathing through a face mask with an ITD (impedance of 6 cm H2O [0.59 kPa]) and 2) breathing through the same face mask with a sham ITD (control). Stroke volume was measured by thoracic bioimpedance. MEASUREMENTS AND MAIN RESULTS: Compared with the control condition, ITD produced higher stroke volume (124 +/- 3 vs. 137 +/- 3 mL; p = .013), heart rate (63 +/- 3 vs. 68 +/- 3 beats/min; p = .049), cardiac output (7.69 vs. 9.34 L/min; p = .001), and systolic blood pressure (115 +/- 2 to 122 +/- 2 mm Hg [15.33 +/- 0.3 to 16.26 +/- 0.3 kPa]; p = .005) without affecting expired minute ventilation (6.2 +/- 0.4 to 6.5 +/- 0.4 L/min; p = .609). CONCLUSIONS: Breathing with an ITD at relatively low impedance increases systolic blood pressure by increasing stroke volume and cardiac output. The ITD may provide short-term protection against cardiovascular collapse induced by orthostatic stress or hemorrhage.

AB - OBJECTIVE: Increased negative intrathoracic pressure during spontaneous inspiration through an impedance threshold device (ITD) causes elevated arterial blood pressure in humans. This study was performed to determine whether the acute increase in blood pressure induced by breathing through an ITD is associated with increased stroke volume and cardiac output. DESIGN: Randomized, blinded, controlled trial. SETTING: Laboratory. SUBJECTS: Ten women and ten men. INTERVENTIONS: We measured hemodynamic and respiratory responses during two separate ITD conditions: 1) breathing through a face mask with an ITD (impedance of 6 cm H2O [0.59 kPa]) and 2) breathing through the same face mask with a sham ITD (control). Stroke volume was measured by thoracic bioimpedance. MEASUREMENTS AND MAIN RESULTS: Compared with the control condition, ITD produced higher stroke volume (124 +/- 3 vs. 137 +/- 3 mL; p = .013), heart rate (63 +/- 3 vs. 68 +/- 3 beats/min; p = .049), cardiac output (7.69 vs. 9.34 L/min; p = .001), and systolic blood pressure (115 +/- 2 to 122 +/- 2 mm Hg [15.33 +/- 0.3 to 16.26 +/- 0.3 kPa]; p = .005) without affecting expired minute ventilation (6.2 +/- 0.4 to 6.5 +/- 0.4 L/min; p = .609). CONCLUSIONS: Breathing with an ITD at relatively low impedance increases systolic blood pressure by increasing stroke volume and cardiac output. The ITD may provide short-term protection against cardiovascular collapse induced by orthostatic stress or hemorrhage.

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