Hemodynamically independent analysis of cerebrospinal fluid and brain motion observed with dynamic phase contrast MRI

Noam Alperin, Eric M. Vikingstad, Beatriz Gomez-Anson, David N. Levin

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Brain and cerebrospinal fluid (CSF) movements are influenced by the anatomy and mechanical properties of intracranial tissues, as well as by the waveforms of driving vascular pulsations. The authors analyze these movements so that the purely hemodynamic factors are removed and the underlying mechanical couplings between brain, CSF, and the vasculature are characterized in global fashion. These measurements were used to calculate a set of impulse response functions or modulation transfer functions, characterizing global aspects of the vasculature's mechanical coupling to the intracranial tissues, the cervical CSF, and the cervical spinal cord. These functions showed that a sudden influx of blood into the head was rapidly accommodated by some type of intracranial reserve or capacity. After this initial response, an equal volume of CSF was driven through the foramen magnum over the next 200-300 ms as the intracranial reserve relaxed to its base-line state.

Original languageEnglish
Pages (from-to)741-754
Number of pages14
JournalMagnetic Resonance in Medicine
Volume35
Issue number5
DOIs
StatePublished - May 1 1996
Externally publishedYes

Fingerprint

Cerebrospinal Fluid
Brain
Foramen Magnum
Blood Vessels
Anatomy
Hemodynamics
Head

Keywords

  • brain
  • cerebrospinal fluid
  • motion
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Hemodynamically independent analysis of cerebrospinal fluid and brain motion observed with dynamic phase contrast MRI. / Alperin, Noam; Vikingstad, Eric M.; Gomez-Anson, Beatriz; Levin, David N.

In: Magnetic Resonance in Medicine, Vol. 35, No. 5, 01.05.1996, p. 741-754.

Research output: Contribution to journalArticle

Alperin, Noam ; Vikingstad, Eric M. ; Gomez-Anson, Beatriz ; Levin, David N. / Hemodynamically independent analysis of cerebrospinal fluid and brain motion observed with dynamic phase contrast MRI. In: Magnetic Resonance in Medicine. 1996 ; Vol. 35, No. 5. pp. 741-754.
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