Abstract
The hemodynamic effects produced by continuous positive airway pressure (CPAP) and continuous negative extrathoracic pressure (CNEP) of 4 and 8 cm H2O were compared in 8 normal, spontaneously breathing piglets. Arterial blood gases and hemodynamic measurements were obtained before and during CPAP and CNEP of 4 and 8 cm H2O. CPAP 8 cm H2O and CNEP 8 cm H2O produced significant increases (p < 0.01) in PaO2 from baselines 76 ± 3 to 85 ± 3 and 77 ± 4 to 85 ± 3 mmHg,respectively. No significant changes occurred in PaCo2 or cardiac index, except during CPAP 8 cm H2O [38 ± 1 to 44 ± 2 mmHg (p < 0.05) and 376 ± 30 to 330 ± 30 ml/kg/min (p < 0.05), respectively]. During CPAP of 4 cm H2O, significant increases occurred in mean right atrial pressure (P̄ra) (2.1 ± 0.3 to 3.3 ± 0.4 mmHg; p < 0.01), left ventricular end-diastolic pressure (LVEDP) (2.8 ± 0.4 to 3.7 ± 0.3 mmHg; p < 0.01), and mean pulmonary artery pressure (P̄pa) (12.9 ± 0.8 to 15.1 ± 0.8 mmHg; p < 0.01). CPAP of 8 cm H2O produced marked increases in P̄ra (2.1 ± 0.2 to 4.9 ± 0.7 mmHg: p < 0.01), LVEDP (2.7 ± 0.5 to 4.5 ± 0.4 mmHg; p < 0.01) and P̄pa (12.8 ± 0.8 to 17.7 ± 0.6 mmHg, p < 0.01). In contrast, CNEP of 8 cm H2O produced decreases in P̄ra (2.1 ± 0.2 to 1.3 ± 0.3 mmHgHg; p < 0.01), LVEDP (2.6 ± 0.5 to 1.7 ± 0.4mmHg; p < 0.01), and P̄pa (12.9 ± 1.0 to 11.4 ± 1.0 mmHg; p < 0.01). CNEP in contrast to CPAP produced an improvement in oxygenation while decreasing vascular pressures and maintaining cardiac output near basal levels. These data support clinical experience which suggests a beneficial effect of CNEP in the treatment of patients with increased pulmonary vascular resistance and pulmonary hypertension.
| Original language | English |
|---|---|
| Pages (from-to) | 69-75 |
| Number of pages | 7 |
| Journal | Biology of the Neonate |
| Volume | 62 |
| Issue number | 2-3 |
| State | Published - Jan 1 1992 |
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Keywords
- Assisted ventilation
- Continuous negative extrathoracic pressure
- Continuous positive airway pressure
- Hemodynamic
- Neonatal
ASJC Scopus subject areas
- Developmental Biology
- Pediatrics, Perinatology, and Child Health
Cite this
Hemodynamic effects of continuous negative extrathoracic pressure and continuous positive airway pressure in piglets with normal lungs. / Adams, J. A.; Osiovich, H.; Goldberg, R. N.; Suguihara, C.; Bancalari, Eduardo.
In: Biology of the Neonate, Vol. 62, No. 2-3, 01.01.1992, p. 69-75.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hemodynamic effects of continuous negative extrathoracic pressure and continuous positive airway pressure in piglets with normal lungs
AU - Adams, J. A.
AU - Osiovich, H.
AU - Goldberg, R. N.
AU - Suguihara, C.
AU - Bancalari, Eduardo
PY - 1992/1/1
Y1 - 1992/1/1
N2 - The hemodynamic effects produced by continuous positive airway pressure (CPAP) and continuous negative extrathoracic pressure (CNEP) of 4 and 8 cm H2O were compared in 8 normal, spontaneously breathing piglets. Arterial blood gases and hemodynamic measurements were obtained before and during CPAP and CNEP of 4 and 8 cm H2O. CPAP 8 cm H2O and CNEP 8 cm H2O produced significant increases (p < 0.01) in PaO2 from baselines 76 ± 3 to 85 ± 3 and 77 ± 4 to 85 ± 3 mmHg,respectively. No significant changes occurred in PaCo2 or cardiac index, except during CPAP 8 cm H2O [38 ± 1 to 44 ± 2 mmHg (p < 0.05) and 376 ± 30 to 330 ± 30 ml/kg/min (p < 0.05), respectively]. During CPAP of 4 cm H2O, significant increases occurred in mean right atrial pressure (P̄ra) (2.1 ± 0.3 to 3.3 ± 0.4 mmHg; p < 0.01), left ventricular end-diastolic pressure (LVEDP) (2.8 ± 0.4 to 3.7 ± 0.3 mmHg; p < 0.01), and mean pulmonary artery pressure (P̄pa) (12.9 ± 0.8 to 15.1 ± 0.8 mmHg; p < 0.01). CPAP of 8 cm H2O produced marked increases in P̄ra (2.1 ± 0.2 to 4.9 ± 0.7 mmHg: p < 0.01), LVEDP (2.7 ± 0.5 to 4.5 ± 0.4 mmHg; p < 0.01) and P̄pa (12.8 ± 0.8 to 17.7 ± 0.6 mmHg, p < 0.01). In contrast, CNEP of 8 cm H2O produced decreases in P̄ra (2.1 ± 0.2 to 1.3 ± 0.3 mmHgHg; p < 0.01), LVEDP (2.6 ± 0.5 to 1.7 ± 0.4mmHg; p < 0.01), and P̄pa (12.9 ± 1.0 to 11.4 ± 1.0 mmHg; p < 0.01). CNEP in contrast to CPAP produced an improvement in oxygenation while decreasing vascular pressures and maintaining cardiac output near basal levels. These data support clinical experience which suggests a beneficial effect of CNEP in the treatment of patients with increased pulmonary vascular resistance and pulmonary hypertension.
AB - The hemodynamic effects produced by continuous positive airway pressure (CPAP) and continuous negative extrathoracic pressure (CNEP) of 4 and 8 cm H2O were compared in 8 normal, spontaneously breathing piglets. Arterial blood gases and hemodynamic measurements were obtained before and during CPAP and CNEP of 4 and 8 cm H2O. CPAP 8 cm H2O and CNEP 8 cm H2O produced significant increases (p < 0.01) in PaO2 from baselines 76 ± 3 to 85 ± 3 and 77 ± 4 to 85 ± 3 mmHg,respectively. No significant changes occurred in PaCo2 or cardiac index, except during CPAP 8 cm H2O [38 ± 1 to 44 ± 2 mmHg (p < 0.05) and 376 ± 30 to 330 ± 30 ml/kg/min (p < 0.05), respectively]. During CPAP of 4 cm H2O, significant increases occurred in mean right atrial pressure (P̄ra) (2.1 ± 0.3 to 3.3 ± 0.4 mmHg; p < 0.01), left ventricular end-diastolic pressure (LVEDP) (2.8 ± 0.4 to 3.7 ± 0.3 mmHg; p < 0.01), and mean pulmonary artery pressure (P̄pa) (12.9 ± 0.8 to 15.1 ± 0.8 mmHg; p < 0.01). CPAP of 8 cm H2O produced marked increases in P̄ra (2.1 ± 0.2 to 4.9 ± 0.7 mmHg: p < 0.01), LVEDP (2.7 ± 0.5 to 4.5 ± 0.4 mmHg; p < 0.01) and P̄pa (12.8 ± 0.8 to 17.7 ± 0.6 mmHg, p < 0.01). In contrast, CNEP of 8 cm H2O produced decreases in P̄ra (2.1 ± 0.2 to 1.3 ± 0.3 mmHgHg; p < 0.01), LVEDP (2.6 ± 0.5 to 1.7 ± 0.4mmHg; p < 0.01), and P̄pa (12.9 ± 1.0 to 11.4 ± 1.0 mmHg; p < 0.01). CNEP in contrast to CPAP produced an improvement in oxygenation while decreasing vascular pressures and maintaining cardiac output near basal levels. These data support clinical experience which suggests a beneficial effect of CNEP in the treatment of patients with increased pulmonary vascular resistance and pulmonary hypertension.
KW - Assisted ventilation
KW - Continuous negative extrathoracic pressure
KW - Continuous positive airway pressure
KW - Hemodynamic
KW - Neonatal
UR - http://www.scopus.com/inward/record.url?scp=0026737986&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026737986&partnerID=8YFLogxK
M3 - Article
C2 - 1420615
AN - SCOPUS:0026737986
VL - 62
SP - 69
EP - 75
JO - Neonatology
JF - Neonatology
SN - 1661-7800
IS - 2-3
ER -