Hemodynamic and ventilatory effects of high-frequency jet and conventional ventilation in piglets with lung lavage

Cleide Suguihara, Eduardo Bancalari, Ronald N. Goldberg, Patricia Barrios, Dorothy Hehre

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17 Scopus citations

Abstract

The cardiovascular and ventilatory effects of high-frequency jet ventilation (HFJV) and conventional ventilation (CV) were evaluated in a saline lung lavage model in piglets. After saline lavage and stabilization on CV, animals were randomized to either mode of ventilation for 4 h. Arterial blood gases, cardiac output, mean pulmonary and arterial blood pressures, and pulmonary and systemic vascular resistances were compared between groups. Alveolar-arterial oxygen gradient (AaDO2) was lower in the HFJV than in the CV group after 3 h ventilation (p < 0.04). The peak inspiratory pressure necessary to maintain PaCO2 within the normal range was approximately half as much in the HFJV group as in the CV group (p < 0.005) throughout the entire study period. Mean airway pressure, cardiac output, mean pulmonary and arterial blood pressures as well as pulmonary and systemic vascular resistances were not statistically different between groups. These results suggest that in this model, HFJV produces better oxygenation with low peak airway pressures compared to CV without producing hemodynamic compromise.

Original languageEnglish (US)
Pages (from-to)241-248
Number of pages8
JournalNeonatology
Volume51
Issue number5
DOIs
StatePublished - Jan 1 1987

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Keywords

  • Conventional ventilation
  • High-frequency jet ventilation
  • Pulmonary function
  • Surfactant deficiency model

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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