Hemodynamic and ventilatory effects of high-frequency jet and conventional ventilation in piglets with lung lavage

C. Suguihara, Eduardo Bancalari, R. N. Goldberg, P. Barrios, D. Hehre

Research output: Contribution to journalArticle

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Abstract

The cardiovascular and ventilatory effects of high-frequency jet ventilation (HFJV) and conventional ventilation (CV) were evaluated in a saline lung lavage model in piglets. After saline lavage and stabilization on CV, animals were randomized to either mode of ventilation for 4 h. Arterial blood gases, cardiac output, mean pulmonary and arterial blood pressures, and pulmonary and systemic vascular resistances were compared between groups. Alveolar-arterial oxygen gradient (AaDO2) was lower in the HFJV than in the CV group after 3 h ventilation (p < 0.04). The peak inspiratory pressure necessary to maintain PaCO2 within the normal range was approximately half as much in the HFJV group as in the CV group (p < 0.005) throughout the entire study period. Mean airway pressure, cardiac output, mean pulmonary and arterial blood pressures as well as pulmonary and systemic vascular resistances were not statistically different between groups. These results suggest that in this model, HFJV produces better oxygenation with low peak airway pressures compared to CV without producing hemodynamic compromise.

Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalBiology of the Neonate
Volume51
Issue number5
StatePublished - Jun 26 1987

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High-Frequency Jet Ventilation
Bronchoalveolar Lavage
Ventilation
Hemodynamics
Vascular Resistance
Pressure
Cardiac Output
Arterial Pressure
Lung
Therapeutic Irrigation
Reference Values
Gases
Oxygen

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Hemodynamic and ventilatory effects of high-frequency jet and conventional ventilation in piglets with lung lavage. / Suguihara, C.; Bancalari, Eduardo; Goldberg, R. N.; Barrios, P.; Hehre, D.

In: Biology of the Neonate, Vol. 51, No. 5, 26.06.1987, p. 241-248.

Research output: Contribution to journalArticle

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