Hemispherectomy in early infantile epileptic encephalopathy

Lorie Hamiwka, Michael Duchowny, Israel Alfonso, Edward Liu

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The authors report the successful surgical treatment of early infantile epileptic encephalopathy and suppression burst in 2 children with hemispheric dysplasia. At surgical evaluation, focal epileptic patterns were recorded from the abnormal hemisphere, and ictal single-photon emission computed tomography demonstrated ipsilateral regional hyperperfusion. Functional hemispherectomy was performed after electrocorticography revealed near-continuous spike and slow-wave discharges over the affected hemisphere. Histopathology revealed Taylor-type cortical dysplasia. Postoperatively, both patients are seizure free on antiepileptic drug monotherapy and have shown improved developmental status. Their favorable outcome demonstrates that children with early infantile epileptic encephalopathy due to unilateral malformations of cortical development may benefit from early surgical intervention.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalJournal of child neurology
Issue number1
StatePublished - Jan 1 2007


  • Childhood epilepsy
  • Early infantile epileptic encephalopathy
  • Epilepsy surgery
  • Hemispherectomy
  • Ohtahara syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health


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