Abstract
We investigated a 6-month-old infant with daily episodes of left hemifacial contraction, head and eye deviation to the right, nystagmoid jerks to the right, autonomic dysfunction, and retained consciousness. The episodes began on day 1 of life and were unresponsive to antiepileptic medication. Interictal and ictal scalp electroencephalographic (EEG) recordings were unremarkable. Magnetic resonance imaging revealed a mass in the left cerebellar hemisphere and peduncle. Ictal single-photon emission computed tomography revealed focal hyperperfusion in the region of the cerebellar mass. Ictal EEG recordings with implanted cerebellar electrodes demonstrated focal seizure discharges in the region of the mass. Resection of the mass resulted in remission of seizures and histopathology revealed ganglioglioma. Six previously reported infants with similar semiology (described as 'hemifacial spasm'), imaging findings, and histopathology are reviewed. We believe the previously reported infants and our patient constitute a rare but important clinicopathological syndrome of infancy characterized by epileptic seizures of cerebellar origin.
| Original language | English |
|---|---|
| Pages (from-to) | 91-98 |
| Number of pages | 8 |
| Journal | Annals of Neurology |
| Volume | 40 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1 1996 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Hemifacial seizures and cerebellar ganglioglioma : An epilepsy syndrome of infancy with seizures of cerebellar origin. / Harvey, A. Simon; Jayakar, Prasanna; Duchowny, Michael; Resnick, Trevor; Prats, Antonio; Altman, Nolan; Renfroe, J. Benjamin.
In: Annals of Neurology, Vol. 40, No. 1, 01.07.1996, p. 91-98.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hemifacial seizures and cerebellar ganglioglioma
T2 - An epilepsy syndrome of infancy with seizures of cerebellar origin
AU - Harvey, A. Simon
AU - Jayakar, Prasanna
AU - Duchowny, Michael
AU - Resnick, Trevor
AU - Prats, Antonio
AU - Altman, Nolan
AU - Renfroe, J. Benjamin
PY - 1996/7/1
Y1 - 1996/7/1
N2 - We investigated a 6-month-old infant with daily episodes of left hemifacial contraction, head and eye deviation to the right, nystagmoid jerks to the right, autonomic dysfunction, and retained consciousness. The episodes began on day 1 of life and were unresponsive to antiepileptic medication. Interictal and ictal scalp electroencephalographic (EEG) recordings were unremarkable. Magnetic resonance imaging revealed a mass in the left cerebellar hemisphere and peduncle. Ictal single-photon emission computed tomography revealed focal hyperperfusion in the region of the cerebellar mass. Ictal EEG recordings with implanted cerebellar electrodes demonstrated focal seizure discharges in the region of the mass. Resection of the mass resulted in remission of seizures and histopathology revealed ganglioglioma. Six previously reported infants with similar semiology (described as 'hemifacial spasm'), imaging findings, and histopathology are reviewed. We believe the previously reported infants and our patient constitute a rare but important clinicopathological syndrome of infancy characterized by epileptic seizures of cerebellar origin.
AB - We investigated a 6-month-old infant with daily episodes of left hemifacial contraction, head and eye deviation to the right, nystagmoid jerks to the right, autonomic dysfunction, and retained consciousness. The episodes began on day 1 of life and were unresponsive to antiepileptic medication. Interictal and ictal scalp electroencephalographic (EEG) recordings were unremarkable. Magnetic resonance imaging revealed a mass in the left cerebellar hemisphere and peduncle. Ictal single-photon emission computed tomography revealed focal hyperperfusion in the region of the cerebellar mass. Ictal EEG recordings with implanted cerebellar electrodes demonstrated focal seizure discharges in the region of the mass. Resection of the mass resulted in remission of seizures and histopathology revealed ganglioglioma. Six previously reported infants with similar semiology (described as 'hemifacial spasm'), imaging findings, and histopathology are reviewed. We believe the previously reported infants and our patient constitute a rare but important clinicopathological syndrome of infancy characterized by epileptic seizures of cerebellar origin.
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U2 - 10.1002/ana.410400115
DO - 10.1002/ana.410400115
M3 - Article
C2 - 8687198
AN - SCOPUS:0029980059
VL - 40
SP - 91
EP - 98
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 1
ER -