Hematoporphyrin photoradiation therapy for iris neovascularization. A preliminary report

A. J. Packer, David Tse, X. Q. Gu, S. S. Hayreh

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Photoradiation therapy is a new technique currently under clinical investigation for the treatment of a variety of solid malignant tumors. The technique involves intravenous (IV) administration of hematoporphyrin derivative, a photosensitizing compound that is preferentially retained by malignant cells, and photoactivation of a neoplasm with red light (632 nm) to obtain selective destruction of cancer cells. A modification of this technique was used to treat iris neovascularization produced in a primate model of retinal vein occlusion. Following IV injection of hematoporphyrin derivative, the anterior surface of the iris was exposed to red light for 30 to 45 minutes. In the four eyes treated, there was a marked reduction of fluorescein leakage from the neovascular tissue within 24 hours following treatment. Histologic examination of two eyes demonstrated a selective response of the iris neovascularization to this therapy, with apparent preservation of surrounding tissue.

Original languageEnglish
Pages (from-to)1193-1197
Number of pages5
JournalArchives of Ophthalmology
Volume102
Issue number8
StatePublished - Jan 1 1984
Externally publishedYes

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Hematoporphyrin Photoradiation
Phototherapy
Iris
Hematoporphyrin Derivative
Tissue Preservation
Light
Retinal Vein Occlusion
Neoplasms
Fluorescein
Intravenous Injections
Intravenous Administration
Primates
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Hematoporphyrin photoradiation therapy for iris neovascularization. A preliminary report. / Packer, A. J.; Tse, David; Gu, X. Q.; Hayreh, S. S.

In: Archives of Ophthalmology, Vol. 102, No. 8, 01.01.1984, p. 1193-1197.

Research output: Contribution to journalArticle

Packer, A. J. ; Tse, David ; Gu, X. Q. ; Hayreh, S. S. / Hematoporphyrin photoradiation therapy for iris neovascularization. A preliminary report. In: Archives of Ophthalmology. 1984 ; Vol. 102, No. 8. pp. 1193-1197.
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