Hematoporphyrin Photoradiation Therapy for Intraocular and Orbital Malignant Melanoma

David T. Tse, Thomas A. Weingeist, Vernon M. Hermsen, Robert C. Kersten, Jonathan J. Dutton

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Photoradiation therapy (PRT) is a new technique that is currently under investigation for the treatment of a variety of solid malignant tumors. The technique involves systemic administration of hematoporphyrin derivative (HpD), a photosensitizing compound that is preferentially retained by malignant cells and photoactivation of the neoplasm with red light (630 nm) to achieve selective destruction of cancer cells. We used HpD PRT for seven patients with malignant melanoma of the uvea and conclude that initial results of HpD PRT for uveal malignant melanoma are encouraging and justify further investigation.

Original languageEnglish (US)
Pages (from-to)833-838
Number of pages6
JournalArchives of ophthalmology
Volume102
Issue number6
DOIs
StatePublished - Jun 1984
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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