Hematopoietic stem cell therapy for type 1 diabetes: Induction of tolerance and islet cell neogenesis

Richard K. Burt, Yu Oyama, Ann Traynor, Norma S. Kenyon

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Diabetes is a chronic disease with significant morbidity and mortality. Pancreas or islet cell transplantation is limited by a shortage of donors and chronic immune suppression to prevent allograft rejection. Consequently, interest exists in islet cell neogenesis from embryonic or mesenchymal stem cell as a possible cure for diabetes. However, unless tolerance to islet cells is re-established, diabetes treated by islet cell transplantation would remain a chronic disease secondary to immune suppression related morbidity. If islet cell tolerance could be re-induced, a major clinical hurdle to curing diabetes by islet cell neogenesis may be overcome. Recent studies suggest that adult hematopoietic stem cells (HSC) can reintroduce tolerance to auto-antigens. It is possible that HSC may also be able to switch lineage and, therefore, be a convenient source of stem cells for both inducing tolerance and islet cell regeneration.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalAutoimmunity Reviews
Volume1
Issue number3
DOIs
StatePublished - May 2002

Keywords

  • Islet cell neogenesis
  • Stem cell therapy
  • Type 1 diabetes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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