Hematopoietic Stem Cell Heterogeneity

Research output: Contribution to journalReview article

Abstract

Hematopoietic stem cells (HSCs) maintain lifelong production of mature blood cells and regenerate the hematopoietic system after cytotoxic injury. Use of expanding cell surface marker panels and advanced functional analyses have revealed the presence of several immunophenotypically different HSC subsets with distinct self-renewal and repopulating capacity and bias toward selective lineage differentiation. This chapter summarizes current understanding of the phenotypic and functional heterogeneity within the HSC pool, with emphasis on the immunophenotypes and functional features of several known HSC subsets, and their roles in steady-state and emergency hematopoiesis, and in aging. The chapter also highlights some of the future research directions to elucidate further the biology and function of different HSC subsets in health and disease states.

Original languageEnglish (US)
Pages (from-to)195-211
Number of pages17
JournalAdvances in experimental medicine and biology
Volume1169
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

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Hematopoietic Stem Cells
Stem cells
Hematopoietic System
Hematopoiesis
Set theory
Blood Cells
Emergencies
Blood
Aging of materials
Cells
Health
Wounds and Injuries

Keywords

  • Hematopoietic stem cellsHematopoiesisHSC subsetsFunctional heterogeneityDifferentiation bias

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hematopoietic Stem Cell Heterogeneity. / Jurecic, Roland.

In: Advances in experimental medicine and biology, Vol. 1169, 01.01.2019, p. 195-211.

Research output: Contribution to journalReview article

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