Hematopoietic reconstitution after lethal irradiation and bone marrow transplantation: Effects of different hematopoietic cytokines on the recovery of thymus, spleen and blood cells

D. Frasca, F. Guidi, M. Arbitrio, C. Pioli, F. Poccia, R. Cicconi, G. Doria

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Lethally irradiated mice were grafted with syngeneic bone marrow cells or left ungrafted. Mice of each group were injected with different hematopoietic cytokines for 5 consecutive days starting immediately after irradiation or left uninjected. The recovery of lymphoid tissues induced by hematopoietic cytokines 7 days after irradiation and bone marrow cell transplantation was comparable to that observed at days 21-28 in irradiated, bone marrow-grafted, but cytokine-uninjected mice. IL-11 or IL-6, in combination with IL-3, was able to hasten thymus, spleen and blood cell numbers and functions. SCF also displayed a detectable effect when used with IL-3. Conversely, the IL-6 superagonist K-7/D-6 was able, when injected alone, to induce significant recovery of thymus, spleen and blood cells. Thus, K-7/D-6 appears to be a most efficient cytokine for fast reconstitution of lymphoid tissues after irradiation and bone marrow transplantation.

Original languageEnglish (US)
Pages (from-to)427-433
Number of pages7
JournalBone Marrow Transplantation
Volume25
Issue number4
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Hematopoietic cytokines
  • Lymphocytes
  • X-rays

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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