Hemangioblastomas: Histogenesis of the stromal cell studied by immunocytochemistry

Stephen Jurco, Mehrdad Nadji, Danny G. Harvey, Joseph C. Parker, Ramon L. Font, Azorides R. Morales

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Twenty-one cases of hemangioblastoma from the cerebellum, spinal cord and retina were studied using the unlabeled antibody peroxidase-antiperoxidase technique with antibodies directed against glial fibrillary acidic protein (GFAP) and factor VIII related antigen (VIIIR:Ag). In 19 of 21 cases studied with anti-GFAP, astrocytes were identified peripherally, and in 13 cases they were found centrally within the tumor. In no instance did stromal cells react positively for GFAP. Sixteen cases with anti-VIIIR: Ag antibody were examined, and in all cases many stromal cells showed positive staining. It is concluded that the stromal cells were of endothelial origin. The occasional stromal cells that other investigators have identified as reacting positively for GFAP may represent stromal cells capable of ingesting extracellular GFAP derived from reactive astrocytes within the tumor, or they may be lipidized astrocytes.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalHuman pathology
Issue number1
StatePublished - Jan 1982
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


Dive into the research topics of 'Hemangioblastomas: Histogenesis of the stromal cell studied by immunocytochemistry'. Together they form a unique fingerprint.

Cite this