Helical chiral pyridine N-oxides: A new family of asymmetric catalysts

Norito Takenaka, Robindro Singh Sarangthem, Burjor Captain

Research output: Contribution to journalArticlepeer-review

181 Scopus citations


(Chemical Equation Presented) Helical Chiral Catalysts: The gram-scale synthesis of 1-azahelicenes, structural characterization of the corresponding N-oxides, and the application of this new family of catalysts to the catalytic, enantioselective ring-opening of meso epoxides is described (see scheme). Included is the first demonstration that the appropriate structural modifications beneath the plane of the pyridine N-oxide can serve as a powerful means for tuning the catalyst enantioselectivity.

Original languageEnglish (US)
Pages (from-to)9708-9710
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number50
StatePublished - Dec 1 2008


  • Atropisomerism
  • Chirality
  • Helical structures
  • Heterocycles
  • Silanes

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis


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