Helical chiral 2,2′-bipyridine N-monoxides as catalysts in the enantioselective propargylation of aldehydes with allenyltrichlorosilane

Jinshui Chen, Burjor Captain, Norito Takenaka

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Abstract

A highly enantioselective synthesis of homopropargylic alcohols is achieved by using the new helical chiral 2,2′-bipyridine N-monoxide catalyst and allenyltrichlorosilane. This method can be further extended to the enantio- and regioselective propargylation of N-acylhydrazones.

Original languageEnglish (US)
Pages (from-to)1654-1657
Number of pages4
JournalOrganic letters
Volume13
Issue number7
DOIs
StatePublished - Apr 1 2011

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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