Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes

Andrea Mistlberger, Jeffrey M. Liebmann, David Greenfield, Mauricio E. Pons, Sek Tien Hoh, Hiroshi Ishikawa, Robert Ritch

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Purpose: To evaluate optic disc and retinal nerve fiber layer (RNFL) appearance in normal, ocular-hypertensive, and glaucomatous eyes undergoing confocal scanning laser ophthalmoscopy and optical coherence tomography (OCT). Design: Prospective, cross-sectional study. Participants: Seventy-eight eyes of 78 consecutive normal (n = 17), ocular-hypertensive (n = 23), and glaucomatous subjects (n = 38) were enrolled. Methods: Each patient underwent complete ophthalmic examination, achromatic automated perimetry, confocal scanning laser ophthalmoscopy (Heidelberg Retinal Tomography [HRT]), and OCT. Topographic HRT parameters (disc area, cup-disc ratio, rim area, rim volume, cup shape measure, mean RNFL thickness, and cross-sectional area) and mean OCT-generated RNFL thickness were evaluated in each group. Main Outcome Measures: OCT and HRT assessment of optic disc and RNFL anatomy. Results: OCT RNFL thickness showed no difference between normal and ocular-hypertensive eyes (P = 0.15) but was significantly less in glaucomatous eyes (P < 0.001). HRT measurements of rim area, cup-disc ratio, cup shape measure, RNFL thickness, and RNFL cross-sectional area were significantly less in glaucomatous eyes (all P < 0.005) and were correlated with mean OCT RNFL thickness (all P < 0.02). RNFL thickness using OCT or HRT was highly correlated with visual field mean defect during achromatic perimetry (P < 0.0001). Conclusion: Both HRT and OCT can differentiate glaucomatous from nonglaucomatous eyes. RNFL thickness measurements using OCT correspond to disc topographic parameters using HRT.

Original languageEnglish
Pages (from-to)2027-2032
Number of pages6
JournalOphthalmology
Volume106
Issue number10
StatePublished - Oct 1 1999

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Optical Coherence Tomography
Nerve Fibers
Retina
Tomography
Ophthalmoscopy
Visual Field Tests
Optic Disk
Lasers
Visual Fields
Anatomy
Cross-Sectional Studies
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Mistlberger, A., Liebmann, J. M., Greenfield, D., Pons, M. E., Hoh, S. T., Ishikawa, H., & Ritch, R. (1999). Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes. Ophthalmology, 106(10), 2027-2032.

Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes. / Mistlberger, Andrea; Liebmann, Jeffrey M.; Greenfield, David; Pons, Mauricio E.; Hoh, Sek Tien; Ishikawa, Hiroshi; Ritch, Robert.

In: Ophthalmology, Vol. 106, No. 10, 01.10.1999, p. 2027-2032.

Research output: Contribution to journalArticle

Mistlberger, A, Liebmann, JM, Greenfield, D, Pons, ME, Hoh, ST, Ishikawa, H & Ritch, R 1999, 'Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes', Ophthalmology, vol. 106, no. 10, pp. 2027-2032.
Mistlberger A, Liebmann JM, Greenfield D, Pons ME, Hoh ST, Ishikawa H et al. Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes. Ophthalmology. 1999 Oct 1;106(10):2027-2032.
Mistlberger, Andrea ; Liebmann, Jeffrey M. ; Greenfield, David ; Pons, Mauricio E. ; Hoh, Sek Tien ; Ishikawa, Hiroshi ; Ritch, Robert. / Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes. In: Ophthalmology. 1999 ; Vol. 106, No. 10. pp. 2027-2032.
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AU - Greenfield, David

AU - Pons, Mauricio E.

AU - Hoh, Sek Tien

AU - Ishikawa, Hiroshi

AU - Ritch, Robert

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