Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes

Andrea Mistlberger, Jeffrey M. Liebmann, David Greenfield, Mauricio E. Pons, Sek Tien Hoh, Hiroshi Ishikawa, Robert Ritch

Research output: Contribution to journalArticle

132 Scopus citations

Abstract

Purpose: To evaluate optic disc and retinal nerve fiber layer (RNFL) appearance in normal, ocular-hypertensive, and glaucomatous eyes undergoing confocal scanning laser ophthalmoscopy and optical coherence tomography (OCT). Design: Prospective, cross-sectional study. Participants: Seventy-eight eyes of 78 consecutive normal (n = 17), ocular-hypertensive (n = 23), and glaucomatous subjects (n = 38) were enrolled. Methods: Each patient underwent complete ophthalmic examination, achromatic automated perimetry, confocal scanning laser ophthalmoscopy (Heidelberg Retinal Tomography [HRT]), and OCT. Topographic HRT parameters (disc area, cup-disc ratio, rim area, rim volume, cup shape measure, mean RNFL thickness, and cross-sectional area) and mean OCT-generated RNFL thickness were evaluated in each group. Main Outcome Measures: OCT and HRT assessment of optic disc and RNFL anatomy. Results: OCT RNFL thickness showed no difference between normal and ocular-hypertensive eyes (P = 0.15) but was significantly less in glaucomatous eyes (P < 0.001). HRT measurements of rim area, cup-disc ratio, cup shape measure, RNFL thickness, and RNFL cross-sectional area were significantly less in glaucomatous eyes (all P < 0.005) and were correlated with mean OCT RNFL thickness (all P < 0.02). RNFL thickness using OCT or HRT was highly correlated with visual field mean defect during achromatic perimetry (P < 0.0001). Conclusion: Both HRT and OCT can differentiate glaucomatous from nonglaucomatous eyes. RNFL thickness measurements using OCT correspond to disc topographic parameters using HRT.

Original languageEnglish
Pages (from-to)2027-2032
Number of pages6
JournalOphthalmology
Volume106
Issue number10
StatePublished - Oct 1 1999

    Fingerprint

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Mistlberger, A., Liebmann, J. M., Greenfield, D., Pons, M. E., Hoh, S. T., Ishikawa, H., & Ritch, R. (1999). Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes. Ophthalmology, 106(10), 2027-2032.