Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2

David J Robbins, Kent E. Nybakken, Ryuji Kobayashi, John C. Sisson, J. Michael Bishop, Pascal P. Thérond

Research output: Contribution to journalArticle

294 Citations (Scopus)

Abstract

The hedgehog gene of Drosophila melanogaster encodes a secreted protein (HH) that plays a vital role in cell fate and patterning. Here we describe a protein complex that mediates signal transduction from HH. The complex includes the products of at least three genes: fused (a protein- serine/threonine kinase), cubitus interruptus (a transcription factor), and costal2 (a kinesin-like protein). The complex binds with great affinity to microtubules in the absence of HH, but binding is reversed by HH. Mutations in the extracatalytic domain of FU abolish both the biological function of the protein and its association with COS2. We conclude that the complex may facilitate signaling from HH by governing access of the cubitus interruptus protein to the nucleus.

Original languageEnglish
Pages (from-to)225-234
Number of pages10
JournalCell
Volume90
Issue number2
DOIs
StatePublished - Jul 25 1997
Externally publishedYes

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Kinesin
Signal transduction
Hedgehogs
Signal Transduction
Proteins
Genes
Protein-Serine-Threonine Kinases
Drosophila melanogaster
Microtubules
Transcription Factors
Association reactions
Mutation

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. / Robbins, David J; Nybakken, Kent E.; Kobayashi, Ryuji; Sisson, John C.; Bishop, J. Michael; Thérond, Pascal P.

In: Cell, Vol. 90, No. 2, 25.07.1997, p. 225-234.

Research output: Contribution to journalArticle

Robbins, David J ; Nybakken, Kent E. ; Kobayashi, Ryuji ; Sisson, John C. ; Bishop, J. Michael ; Thérond, Pascal P. / Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. In: Cell. 1997 ; Vol. 90, No. 2. pp. 225-234.
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