Abstract
Alopecia areata (AA) is a common autoimmune disease characterized by non-scarring hair loss. Previous studies have demonstrated an association between AA and physiological/psychological stress. In this study, we investigated the effects of heat treatment, a physiological stress, on AA development in C3H/HeJ mice. Whereas this strain of mice are predisposed to AA at low incidence by 18 months of age, we observed a significant increase in the incidence of hair loss in heat-treated 8-month-old C3H/HeJ mice compared with sham-treated mice. Histological analysis detected mononuclear cell infiltration in anagen hair follicles, a characteristic of AA, in heat-treated mouse skin. As expected, increased expression of induced HSPA1A/B (formerly called HSP70i) was detected in skin samples from heat-treated mice. Importantly, increased HSPA1A/B expression was also detected in skin samples from C3H/HeJ mice that developed AA spontaneously. Our results suggest that induction of HSPA1A/B may precipitate the development of AA in C3H/HeJ mice. For future studies, the C3H/HeJ mice with heat treatment may prove a useful model to investigate stress response in AA.
| Original language | English |
|---|---|
| Pages (from-to) | 985-991 |
| Number of pages | 7 |
| Journal | Cell Stress and Chaperones |
| Volume | 15 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 1 2010 |
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Keywords
- Alopecia areata
- C3H/HeJ
- Heat shock
- Stress
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
Cite this
Heat treatment increases the incidence of alopecia areata in the C3H/HeJ mouse model. / Wikramanayake, Tongyu; Alvarez-Connelly, Elizabeth; Simon, Jessica; Mauro, Lucia M.; Guzman, Javier; Elgart, George; Schachner, Lawrence A; Chen, Juan; Plano, Lisa R.; Jimenez, Joaquin J.
In: Cell Stress and Chaperones, Vol. 15, No. 6, 01.11.2010, p. 985-991.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heat treatment increases the incidence of alopecia areata in the C3H/HeJ mouse model
AU - Wikramanayake, Tongyu
AU - Alvarez-Connelly, Elizabeth
AU - Simon, Jessica
AU - Mauro, Lucia M.
AU - Guzman, Javier
AU - Elgart, George
AU - Schachner, Lawrence A
AU - Chen, Juan
AU - Plano, Lisa R.
AU - Jimenez, Joaquin J
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Alopecia areata (AA) is a common autoimmune disease characterized by non-scarring hair loss. Previous studies have demonstrated an association between AA and physiological/psychological stress. In this study, we investigated the effects of heat treatment, a physiological stress, on AA development in C3H/HeJ mice. Whereas this strain of mice are predisposed to AA at low incidence by 18 months of age, we observed a significant increase in the incidence of hair loss in heat-treated 8-month-old C3H/HeJ mice compared with sham-treated mice. Histological analysis detected mononuclear cell infiltration in anagen hair follicles, a characteristic of AA, in heat-treated mouse skin. As expected, increased expression of induced HSPA1A/B (formerly called HSP70i) was detected in skin samples from heat-treated mice. Importantly, increased HSPA1A/B expression was also detected in skin samples from C3H/HeJ mice that developed AA spontaneously. Our results suggest that induction of HSPA1A/B may precipitate the development of AA in C3H/HeJ mice. For future studies, the C3H/HeJ mice with heat treatment may prove a useful model to investigate stress response in AA.
AB - Alopecia areata (AA) is a common autoimmune disease characterized by non-scarring hair loss. Previous studies have demonstrated an association between AA and physiological/psychological stress. In this study, we investigated the effects of heat treatment, a physiological stress, on AA development in C3H/HeJ mice. Whereas this strain of mice are predisposed to AA at low incidence by 18 months of age, we observed a significant increase in the incidence of hair loss in heat-treated 8-month-old C3H/HeJ mice compared with sham-treated mice. Histological analysis detected mononuclear cell infiltration in anagen hair follicles, a characteristic of AA, in heat-treated mouse skin. As expected, increased expression of induced HSPA1A/B (formerly called HSP70i) was detected in skin samples from heat-treated mice. Importantly, increased HSPA1A/B expression was also detected in skin samples from C3H/HeJ mice that developed AA spontaneously. Our results suggest that induction of HSPA1A/B may precipitate the development of AA in C3H/HeJ mice. For future studies, the C3H/HeJ mice with heat treatment may prove a useful model to investigate stress response in AA.
KW - Alopecia areata
KW - C3H/HeJ
KW - Heat shock
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=78149469723&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78149469723&partnerID=8YFLogxK
U2 - 10.1007/s12192-010-0209-7
DO - 10.1007/s12192-010-0209-7
M3 - Article
C2 - 20582641
AN - SCOPUS:78149469723
VL - 15
SP - 985
EP - 991
JO - Cell Stress and Chaperones
JF - Cell Stress and Chaperones
SN - 1355-8145
IS - 6
ER -