“Heat shock protein 70 in pancreatic diseases: Friend or foe”

Bhuwan Giri, Vrishketan Sethi, Shrey Modi, Bharti Garg, Sulagna Banerjee, Ashok Saluja, Vikas Dudeja

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

The heat shock response in pancreatitis that is activated via HSP70 protects acinar cells through multiple simultaneous mechanisms. It inhibits trypsinogen activation and modulates NF-κB signaling to limit acinar cell injury. On the other hand, HSP70 is overexpressed in pancreatic cancer and is hijacked by the cellular machinery to inhibit apoptosis. Inhibition of HSP70 in pancreatic cancer by a novel compound, Minnelide, has shown considerable clinical promise.

Original languageEnglish (US)
Pages (from-to)114-122
Number of pages9
JournalJournal of Surgical Oncology
Volume116
Issue number1
DOIs
StatePublished - Jul 1 2017

Fingerprint

Pancreatic Diseases
HSP70 Heat-Shock Proteins
Acinar Cells
Pancreatic Neoplasms
Trypsinogen
Heat-Shock Response
Pancreatitis
Apoptosis
Wounds and Injuries
14-O-phosphonooxymethyltriptolide

Keywords

  • calcium
  • HSP70
  • lysosomes
  • minnelide
  • pancreatic cancer
  • pancreatitis
  • triptolide

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

“Heat shock protein 70 in pancreatic diseases : Friend or foe”. / Giri, Bhuwan; Sethi, Vrishketan; Modi, Shrey; Garg, Bharti; Banerjee, Sulagna; Saluja, Ashok; Dudeja, Vikas.

In: Journal of Surgical Oncology, Vol. 116, No. 1, 01.07.2017, p. 114-122.

Research output: Contribution to journalReview article

Giri, Bhuwan ; Sethi, Vrishketan ; Modi, Shrey ; Garg, Bharti ; Banerjee, Sulagna ; Saluja, Ashok ; Dudeja, Vikas. / “Heat shock protein 70 in pancreatic diseases : Friend or foe”. In: Journal of Surgical Oncology. 2017 ; Vol. 116, No. 1. pp. 114-122.
@article{bbf359c3480d4cfda2228fa612a7ed91,
title = "“Heat shock protein 70 in pancreatic diseases: Friend or foe”",
abstract = "The heat shock response in pancreatitis that is activated via HSP70 protects acinar cells through multiple simultaneous mechanisms. It inhibits trypsinogen activation and modulates NF-κB signaling to limit acinar cell injury. On the other hand, HSP70 is overexpressed in pancreatic cancer and is hijacked by the cellular machinery to inhibit apoptosis. Inhibition of HSP70 in pancreatic cancer by a novel compound, Minnelide, has shown considerable clinical promise.",
keywords = "calcium, HSP70, lysosomes, minnelide, pancreatic cancer, pancreatitis, triptolide",
author = "Bhuwan Giri and Vrishketan Sethi and Shrey Modi and Bharti Garg and Sulagna Banerjee and Ashok Saluja and Vikas Dudeja",
year = "2017",
month = "7",
day = "1",
doi = "10.1002/jso.24653",
language = "English (US)",
volume = "116",
pages = "114--122",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - “Heat shock protein 70 in pancreatic diseases

T2 - Friend or foe”

AU - Giri, Bhuwan

AU - Sethi, Vrishketan

AU - Modi, Shrey

AU - Garg, Bharti

AU - Banerjee, Sulagna

AU - Saluja, Ashok

AU - Dudeja, Vikas

PY - 2017/7/1

Y1 - 2017/7/1

N2 - The heat shock response in pancreatitis that is activated via HSP70 protects acinar cells through multiple simultaneous mechanisms. It inhibits trypsinogen activation and modulates NF-κB signaling to limit acinar cell injury. On the other hand, HSP70 is overexpressed in pancreatic cancer and is hijacked by the cellular machinery to inhibit apoptosis. Inhibition of HSP70 in pancreatic cancer by a novel compound, Minnelide, has shown considerable clinical promise.

AB - The heat shock response in pancreatitis that is activated via HSP70 protects acinar cells through multiple simultaneous mechanisms. It inhibits trypsinogen activation and modulates NF-κB signaling to limit acinar cell injury. On the other hand, HSP70 is overexpressed in pancreatic cancer and is hijacked by the cellular machinery to inhibit apoptosis. Inhibition of HSP70 in pancreatic cancer by a novel compound, Minnelide, has shown considerable clinical promise.

KW - calcium

KW - HSP70

KW - lysosomes

KW - minnelide

KW - pancreatic cancer

KW - pancreatitis

KW - triptolide

UR - http://www.scopus.com/inward/record.url?scp=85019620423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019620423&partnerID=8YFLogxK

U2 - 10.1002/jso.24653

DO - 10.1002/jso.24653

M3 - Review article

C2 - 28543919

AN - SCOPUS:85019620423

VL - 116

SP - 114

EP - 122

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 1

ER -