Abstract
The heat shock response in pancreatitis that is activated via HSP70 protects acinar cells through multiple simultaneous mechanisms. It inhibits trypsinogen activation and modulates NF-κB signaling to limit acinar cell injury. On the other hand, HSP70 is overexpressed in pancreatic cancer and is hijacked by the cellular machinery to inhibit apoptosis. Inhibition of HSP70 in pancreatic cancer by a novel compound, Minnelide, has shown considerable clinical promise.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 114-122 |
| Number of pages | 9 |
| Journal | Journal of Surgical Oncology |
| Volume | 116 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1 2017 |
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Keywords
- calcium
- HSP70
- lysosomes
- minnelide
- pancreatic cancer
- pancreatitis
- triptolide
ASJC Scopus subject areas
- Surgery
- Oncology
Cite this
“Heat shock protein 70 in pancreatic diseases : Friend or foe”. / Giri, Bhuwan; Sethi, Vrishketan; Modi, Shrey; Garg, Bharti; Banerjee, Sulagna; Saluja, Ashok; Dudeja, Vikas.
In: Journal of Surgical Oncology, Vol. 116, No. 1, 01.07.2017, p. 114-122.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - “Heat shock protein 70 in pancreatic diseases
T2 - Friend or foe”
AU - Giri, Bhuwan
AU - Sethi, Vrishketan
AU - Modi, Shrey
AU - Garg, Bharti
AU - Banerjee, Sulagna
AU - Saluja, Ashok
AU - Dudeja, Vikas
PY - 2017/7/1
Y1 - 2017/7/1
N2 - The heat shock response in pancreatitis that is activated via HSP70 protects acinar cells through multiple simultaneous mechanisms. It inhibits trypsinogen activation and modulates NF-κB signaling to limit acinar cell injury. On the other hand, HSP70 is overexpressed in pancreatic cancer and is hijacked by the cellular machinery to inhibit apoptosis. Inhibition of HSP70 in pancreatic cancer by a novel compound, Minnelide, has shown considerable clinical promise.
AB - The heat shock response in pancreatitis that is activated via HSP70 protects acinar cells through multiple simultaneous mechanisms. It inhibits trypsinogen activation and modulates NF-κB signaling to limit acinar cell injury. On the other hand, HSP70 is overexpressed in pancreatic cancer and is hijacked by the cellular machinery to inhibit apoptosis. Inhibition of HSP70 in pancreatic cancer by a novel compound, Minnelide, has shown considerable clinical promise.
KW - calcium
KW - HSP70
KW - lysosomes
KW - minnelide
KW - pancreatic cancer
KW - pancreatitis
KW - triptolide
UR - http://www.scopus.com/inward/record.url?scp=85019620423&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019620423&partnerID=8YFLogxK
U2 - 10.1002/jso.24653
DO - 10.1002/jso.24653
M3 - Review article
C2 - 28543919
AN - SCOPUS:85019620423
VL - 116
SP - 114
EP - 122
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 1
ER -