Heat as an agent producing high frequency of mutations and unstable genes in Escherichia coli

Stephen Zamenhof, Sheldon Greer

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

MILD heating (up to 36°C.) is known to produce a small increase of the spontaneous mutation-rates in Drosophila and in bacteria. We have found that using special conditions it is possible to have mesophilic non-sporogenic bacteria (Escherichia coli) survive relatively high temperatures (60°C.) ; this sublethal treatment produces a high frequency of mutations and unstable genes.

Original languageEnglish (US)
Pages (from-to)611-613
Number of pages3
JournalNature
Volume182
Issue number4635
DOIs
StatePublished - Dec 1 1958

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