Heat as an agent producing high frequency of mutations and unstable genes in Escherichia coli

Stephen Zamenhof, Sheldon Greer

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

MILD heating (up to 36°C.) is known to produce a small increase of the spontaneous mutation-rates in Drosophila and in bacteria. We have found that using special conditions it is possible to have mesophilic non-sporogenic bacteria (Escherichia coli) survive relatively high temperatures (60°C.) ; this sublethal treatment produces a high frequency of mutations and unstable genes.

Original languageEnglish
Pages (from-to)611-613
Number of pages3
JournalNature
Volume182
Issue number4635
DOIs
StatePublished - Dec 1 1958
Externally publishedYes

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Mutation Rate
Hot Temperature
Escherichia coli
Bacteria
Heating
Genes
Drosophila
Temperature

ASJC Scopus subject areas

  • General

Cite this

Heat as an agent producing high frequency of mutations and unstable genes in Escherichia coli. / Zamenhof, Stephen; Greer, Sheldon.

In: Nature, Vol. 182, No. 4635, 01.12.1958, p. 611-613.

Research output: Contribution to journalArticle

Zamenhof, Stephen ; Greer, Sheldon. / Heat as an agent producing high frequency of mutations and unstable genes in Escherichia coli. In: Nature. 1958 ; Vol. 182, No. 4635. pp. 611-613.
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